摘要
谷氨酰胺 ( Gln)是循环和体内氨基酸池中含量最丰富的氨基酸 :创伤后机体免疫功能损害与血中谷氨酰胺浓度下降密切相关。单核巨噬细胞是免疫系统的组成部分 ,在免疫反应中起重要作用。研究表明谷氨酰胺是单核巨噬细胞主要的代谢底物 ,通过谷氨酰胺酵解途径 ,为细胞代谢提供能量 ;为细胞合成 DNA和 m RNA提供嘌呤、嘧啶、核苷酸生物合成前体 ;提供氨基葡萄糖 ,GTP和 NAD+合成的氮前体。单核巨噬细胞的免疫功能依赖于谷氨酰胺的含量 ,包括吞噬功能、细胞因子合成和分泌以及抗原提呈等功能。通过特殊的营养支持以增加肌肉和血中 Gln浓度 ,改善应激状态下的免疫功能抑制 。
Glutamine is the most abundant amino acid in the blood and in the free amino acid pool of body.Macrophage is the major cellular component of the immune system,and plays sever al important roles in the immune response.Decrease in plasma glutamine resulting from trauma may be responsible for the impairment of immune function.Most of the studies have demonstrated that glutamine serves metabolic roles for macrophage.By glutamiolysis pathway,glutamine pro vides ATP for the cellular metabolism,intermediates for the biosynthesis of parine,pyrimidine and nuclecotides,and nitrogen for the formation of glucosamine,GTP and NAD+.The immune function of macrophage including phagocytosis,synthesis of cytokines,and antigen processing and presentation depends on glutamine.Administration of glutamine is beneficial in stress situations.
出处
《肠外与肠内营养》
CAS
2000年第3期166-170,共5页
Parenteral & Enteral Nutrition
关键词
谷氨酰胺
巨噬细胞
代谢
免疫调节
Glutamine
Macrophage
Metabolism
Immunomodulation
