摘要
近年来,2型糖尿病在全球范围发病率迅速增加,并且有发病时间年轻化的趋势。因此,寻求新的预防和治疗方法成为了亟待解决的问题。胰岛素在维持血糖平衡的过程中起到了不可或缺的作用。胰岛素主要是通过PI3K/AKT信号通路行使其调控血糖的功能。对胰岛素刺激下的PI3K/AKT信号通路的分子机制进行了详细的阐述,分析了在小鼠模型中基因敲除PI3K/AKT信号通路中各个分子以及其负调控因子对糖代谢过程产生的影响,讨论了如何将这些理论研究向临床应用进行转化。另外,还对PAQR3在胰岛素信号通路中的生理功能进行了分析讨论,揭示了一个全新的空间调控胰岛素信号通路的机制。
Type 2 diabetes is a chronic metabolic disease, which is prevalent in nearly all populations in the world and the onset of diabetes is earlier than before. Thus, new therapeutic approaches to counter the increasing threat of type 2 diabetes are in high demand. Insulin is an indispensable regulator of glucose homeostasis. The PI3K/AKT signaling pathway is required for insulin-dependent regulation on cellular metabolism. Here we review the mechanisms of signal transduction implicated in PI3K/AKT and their roles in modulating glucose homeostasis including the studies using transgenic and knockout mouse models. We also discuss how to translate the knowledge of basic research into clinical practice. In addition, we discuss our recent discovery about the regulation of insulin signaling and function by PAQR3.
出处
《生命科学》
CSCD
2013年第2期133-139,共7页
Chinese Bulletin of Life Sciences
基金
国家自然科学基金项目(81021002和81130077)
