摘要
目的:总结吡柔比星(THP)膀胱灌注联合乌苯美司片预防浅表性膀胱癌术后复发的疗效及安全性。方法:2008年10月～2011年10月对103例浅表性膀胱尿路上皮癌患者行经尿道膀胱肿瘤切除(TURBT)术,术后分成两组,其中THP膀胱灌注联合乌苯美司片组56例,单纯THP膀胱灌注组47例。THP灌注方法为30mg/次,每次膀胱内保留30min,每周1次共8次,然后每月1次共8次;乌苯美司片服法30mg/d,早晨顿服,连用10个月。定期行膀胱镜检查。结果:103例患者获得随访,平均随访(12.5±6.28)个月,THP联合乌苯美司组1年和2年复发率分别为8.9%和10.7%;单纯THP组1年和2年复发率分别为12.8%和19.1%,差异有统计学意义。THP联合乌苯美司组副作用主要为膀胱刺激征及轻微血尿,全身副作用少,症状轻,较单纯THP组无明显差异。结论:THP膀胱灌注联合乌苯美司片预防浅表性膀胱癌术后复发疗效满意,副作用以下尿路局部症状为主,安全性好。
Objective：To evaluate the effect and safety of the application of intravesical instillation of pirarubicin（THP） combined with ubenimex for prevention from recurrences in patients with superficial bladder cancer. Methods： After TURBT 103 patients with superficial bladder carcinoma were divided into two groups. The first group of 56 patients were performed by THP intravesical instillation combined with ubenimex while the second group of 47 patients were performed by THP intravesical instillation, lntravesical instillation of THP was given at a dose of 30 mg every week for 8 consective weeks then every month for 8 months, the retention time in bladder was 30 min. Ubenimex was administered at a dose of 30 mg every morning for 10 consective weeks. Cystoscope was performed regularly. Results： All the patients were followed up for an average time of （12.5＋6.28）months. The 2 and 5-year recurrence was 8.9% and 10.7% in the first group, but 12.8% and 19.1% in the second group. The difference is of statistical significance. The patients of first group had irritation sign of bladder as well as slight blood urine, with few general side effects and slight symptoms. There was no significant difference of side effects between two groups. Conclusions：The administration of intravesical instillation of T HP combined with ube nimex for prevention from postoperative recurrences was satisfactory, effective and safe, the side effects of treatment are mainly local bladder symptoms.
出处
《临床泌尿外科杂志》
2013年第3期204-206,共3页
Journal of Clinical Urology
关键词
膀胱癌
吡柔比星
乌苯美司
膀胱灌注
bladder cancer
pirarubicin
ubenimex
imravesical instillation
