摘要
目的:观察丹参川芎嗪注射液联合大剂量黄芪注射液治疗糖尿病肾病(DN)的临床效果。方法:将我院DN患者80例随机均分为治疗组和对照组,除常规西医治疗外,治疗组采用丹参川芎嗪注射液10ml加入0.9%氯化钠注射液250ml中静脉滴注,同时以黄芪注射液60ml加入0.9%氯化钠注射液200～400ml中静脉滴注,黄芪注射液于3～5d内加至总量120ml;对照组仅采用丹参川芎嗪注射液10ml加入0.9%氯化钠注射液250ml中静脉滴注。两组患者疗程均为21d。观察两组患者治疗前后血液流变学、肾功能指标以及临床症状体征变化情况,同时监测不良反应发生情况。结果:治疗组和对照组患者治疗前、后血液流变学指标的改善差异均有统计学意义(P<0.05),且两组患者治疗后血液流变学指标比较差异无统计学意义(P>0.05);两组患者治疗前、后肾功能指标的改善差异均有统计学意义(P<0.05),且治疗组治疗后24h尿蛋白定量(24hUPQ)、尿素氮(BUN)、肌酐(Scr)等指标相比对照组下降更显著,组间差异有统计学意义(P<0.05);治疗后治疗组患者相比对照组面浮肢肿、畏寒肢冷、腰酸膝软、神疲乏力等临床症状体征有明显改善;两组患者均未见明显不良反应发生。结论:丹参川芎嗪注射液联合大剂量黄芪注射液能明显降低DN患者尿蛋白,改善肾功能和临床症状体征,且安全性较好。
OBJECTIVE： To observe clinical effects of Salvia miltiorrhiza ligustrazine injection combined with large-dose Astragalus membranaceus injection on diabetic nephropathy （DN）. METHODS： 80 DN patients were randomly divided into treatment group and control group. Except conventional western medicine treatment, S. miltiorrhiza ligustrazine injection 10 ml combined with 0.9% Sodium chloride injection 250 ml was used in treatment group, and A. membranaceus injection 60 ml added into 0.9% Sodium chloride injection 200-400 ml was used intravenously with the amount of A. membranaceus injection increasing to 120 ml within 3-5 d. Control group only received S. miltiorrhiza ligustrazine injection 10 ml combined with 0.9% Sodium chloride injection 250 ro1 intravenously. The treatment course for both groups was 21 d. Changes of blood rheology, renal function and clinical symptoms and signs were observed in 2 groups before and after treatment, while ADR monitoring was carried out simultaneously. RESULTS： There was statistical significance in the improvement of blood rheology index between 2 groups before and after treatment （P〈0.05）, and there was no statistical significance in blood rheology index between 2 groups after treatment （P〉0.05）. There was statistical significance in the improvement of renal function between 2 groups before and after treatment （P〈0.05）. Compared with control group, 24 h UPQ, BUN and Scr of treatment group decreased significantly, there was statistical significance between 2 groups （P〈0.05） ; bloated face and limb edema, cold extremities, ache and weak at waist and knee, fatigue and other clinical manifestations were improved significantly in treatment group after treatment, compared with control group. No obvious ADR was found in 2 groups. CONCLUSIONS： S. miltiorrhiza ligustrazine injection combined with high-dose A. membranaceus injection can significantly reduce the albuminuria and improve the renal function and clinical symptoms in DN patients with sound safety.
出处
《中国药房》
CAS
CSCD
2013年第12期1094-1095,共2页
China Pharmacy
关键词
丹参川芎嗪注射液
黄芪注射液
糖尿病肾病
尿蛋白定量
尿素氮
肌酐
Salvia miltiorrhiza ligustrazine injection
Astragalus membranaceus injection
Diabetic nephropathy
Proteinuria
Usea nitroren
Creatinine
