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载脂蛋白L与动脉粥样硬化的研究进展

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摘要 载脂蛋白L(apolipoproteinL,apoL)是一种新发现的高密度脂蛋白(HDL),在临床上具有诱导细胞凋亡的作用。近期发现,动脉硬化过程中,内皮细胞在长期慢性炎症的刺激下分泌大量肿瘤坏死因子-α可上调ApoL的表达,其在动脉粥样硬化斑块中高表达可通过多种机制引起在动脉硬化起主要作用的细胞如巨噬细胞、内皮细胞和血管平滑肌细胞凋亡,加速动脉硬化进展。本文针对载脂蛋白ApoL诱导细胞凋亡及其对动脉硬化的作用作一综述。
出处 《心血管病防治知识(学术版)》 2013年第3期65-68,共4页 Prevention and Treatment of Cardiovascular Disease
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参考文献23

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