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CK5/6、CK7、TTF-1和Ki-67在肺黏液表皮样癌中的表达及意义

Expression and significance of CK5/6, CK7, TTF-1 and Ki-67 in pulmonary mucoepidermoid carcinoma
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摘要 目的探讨CK5/6、CK7、TTF-1和Ki-67对肺黏液表皮样癌的诊断意义。方法应用免疫组织化学检测CK5/6、CK7、TTF-1和Ki-67在13例肺黏液表皮样癌、28例肺腺癌、23例肺鳞状细胞癌(鳞癌)中的表达。结果 CK5/6在黏液表皮样癌与腺癌、CK7在黏液表皮样癌与鳞癌中表达差异均有统计学差异(P<0.01),TTF-1在腺癌中表达显著高于黏液表皮样癌和鳞癌(P<0.01),Ki-67在腺癌和鳞癌中表达均高于黏液表皮样癌(P<0.05)。结论联合检测CK5/6、CK7、TTF-1和Ki-67有助于肺黏液表皮样癌与肺腺癌、鳞癌的鉴别。 Objective To study the diagnostic value of CK5/6, CK7, TTF-1 and Ki-67 expression in pulmonary mucoepider- moid carcinoma （MEC）. Method CK5/6, CK7, TTF-1 and Ki-67 expression was detected by irnmunohistochemistry in 13 pulmonary MEC, 28 adenocarcinoma and 23 squamous cell carcinoma （SCC） cases. Results There were significant differences in CK5/6 expression between MEC and adenocarcinoma and in CK7 between MEC and SCC （P〈0.01）. TTF-1 expression in adenocarcinoma was superior to that in MEC and SCC （P〈0.01）, while Ki-67 expression was significantly higher in adenocarcinoma and SCC than that in MEC （P〈0.05）. Conclusion Combined detection of CK5/6, CKT, TTF-1 and Ki-67 expression is helpful for differential diagnosis of pulmonary MEC, adenocarcinoma and SCC.
作者 吴艳霞 吴冬梅
机构地区 广东医学院附属医院病理科
出处 《广东医学院学报》 2012年第6期605-607,共3页 Journal of Guangdong Medical College
关键词 黏液表皮样癌 CK5/6 CK7 TTF-1 KI-67 mucoepidermoid carcinoma CK5/6 CK7 TTF- 1 Ki-67
分类号 R734.2 [医药卫生—肿瘤]
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参考文献8

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二级参考文献12

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广东医学院学报
2012年 第6期

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