摘要
目的观察α-硫辛酸联合血栓通治疗糖尿病周围神经病变的临床疗效，探索治疗糖尿病周围神经病变的方法。方法将确诊的87例糖尿病性周围神经病变患者随机分为治疗组44例和对照组43例，治疗组给予血栓通（三七总皂苷）450mg／d，α-硫辛酸600mg／d；对照组给予血栓通450mg／d，均分别加人0．9％氯化钠注射液250mL静脉滴注。两组均15d为1个疗程，间隔3～5d再进入下1个疗程，连用2个疗程。比较两组患者治疗前后神经传导速度及临床症状改善情况，并观察药物不良反应。结果治疗后两组患者的神经传导速度及临床症状均较治疗前有改善（P〈0．05），治疗组改善显著优于对照组，差异有统计学意义（P〈0．05）。结论α-硫辛酸联合血栓通可以明显改善糖尿病周围神经病变症状，疗效优于单独使用血栓通，可以作为治疗糖尿病周围神经病变较好的治疗方法。
Objective To observe the clinical effects of Xueshuantong and alpha lipoic acid on diabetic peripheral neuropathy(DPN) and explored the method of treating DPN. Methods The 87 DPN patients were randomly divided into 2 groups:the treatment group with injection Xueshuantong 450mg/d and alpha lipoic acid 600 mg/d (n=44) and the control group with Xueshuantong 450 mg/d(n=43).Each treatment lasted for a course of 15 days and interrupted 3-5 days before the next course. Results Treatment group versus control group improved motor nerve conduction velocity in median nerve and peroneal nerve and also relieved clinical symptoms(P<0.05). Conclusion The clinical effects of Xueshuantong and alpha lipoicacid on diabetic peripheral neuropathy were better than Xueshuantong alone.
出处
《中国医药科学》
2013年第4期177-178,185,共3页
China Medicine And Pharmacy
