摘要
目的观察奥美拉唑与雷尼替丁治疗Hp阳性消化性溃疡的临床疗效,探讨奥美拉唑治疗Hp阳性消化性溃疡的临床价值及意义。方法将82例Hp阳性消化性溃疡患者随机分为奥美拉唑组与雷尼替丁组各41例,分别给予奥美拉唑与雷尼替丁治疗,观察两组患者临床疗效及不良反应情况。结果奥美拉唑组治愈率为97.56%,雷尼替汀组治愈率为65.85%,奥美拉唑组治愈率明显高于雷尼替汀组(P<0.01);奥美拉唑Hp根除率为92.68%,雷尼替汀组Hp根除率为51.22%,奥美拉唑组Hp根除率明显高于雷尼替汀组(P<0.01);两组患者不良反应发生率比较差异无统计学意义(P>0.05)。结论奥美拉唑为主的三联疗法治疗Hp阳性消化性溃疡具有疗效好、Hp根除彻底、不良反应少等诸多优点,可作为目前治疗Hp阳性消化性溃疡的一种首先方案。
Objective To investigate the clinical efficacy of omeprazole and ranitidine on the treatment of Hp positive peptic ulcer and discuss the clinical values and significance of omeprazole on the treatment of Hp positive peptic ulcer. Methods 82 cases of Hp positive peptic ulcer were randomly divided into the omeprazole group and the ranitidine group （each with 41 cases）. Both groups were treated with omeprazole and ranitidine respecitvely. Observations were carried out about the clinical efficacy and adverse reactions of both groups. Results The recovery rate of the omeprazole group was 97.56%,while the recovery rate of the ranitidine group was 65.85%,the former was significantly higher than the latter （P 〈 0.01）.The eradication rate of the ranitidine group was 51.22%,and the eradication rate of the omeprazole group was significantly higher than that of the ranitidine （P＇〈 0.01）. There was nO significant difference between both groups in the incurrence rate of adverse reactions （P 〉 0.05）. Conclusion With good efficacy,complete eradication of Hp,and few adverse reactions,the triple therapy dominiated with omeprazole serves as a priority in the treatment of Hp positive peptic ulcer nowadays.
出处
《中国医药科学》
2013年第3期95-96,共2页
China Medicine And Pharmacy
