摘要
目的探讨三种不同病理类型的消化道来源卵巢转移性肿瘤(印戒细胞癌、腺癌、粘液性腺癌)的临床病理特征。方法回顾性对比分析2009年1月-2012年8月就诊于吉林大学第二医院妇科的46例消化道来源卵巢转移性肿瘤—印戒细胞癌(18例)、腺癌(16例)、粘液性腺癌(12例)患者的临床病理特征。结果所有患者的平均年龄为50岁(23-91)。35例(76.1%)患者发现消化道原发灶,包括胃17例(48.6%),结直肠18例(51.4%)。印戒细胞癌大多来源于胃(93.8%),腺癌及粘液性腺癌的原发灶多位于结直肠(89.4%),两者比较具有统计学意义(P=0.000)。31例(67.4%)出现双侧卵巢转移,三者中分别有16例(88.9%)、7例(43.8%)、8例(66.7%),印戒细胞癌和腺癌比较有统计学意义(P=0.000)。三者中CK7表达阳性者分别为7例(7/8,87.5%)、2例(2/9,22.2%)、7例(7/11,63.6%),整体比较有统计学意义(P=0.022),两两比较印戒细胞癌与腺癌有统计学意义(P=0.015)。CK7(+)/CK20(+)在三者中分别为7例(87.5%)、2例(22.2%)、5例(45.5%),整体比较有统计学意义(P=0.037),印戒细胞癌与腺癌比较有统计学意义(P=0.015),印戒细胞癌与(腺癌+粘液性腺癌)比较有统计学意义(P=0.033)。CK7(-)/CK20(+)在三者中分别为1例(12.5%)、6例(66.7%)、4例(36.4%),三者比较无统计学意义(P=0.079)。结论印戒细胞癌多来源于胃,多CK7(+)/CK20(+),常见双侧转移。腺癌多来源于结直肠,多CK7(-)/CK20(+)。粘液性腺癌多来源于结直肠。
Objective To analyze and summarize the clinical and pathological features of th：ree kinds of different pathological metastatic ovarian tumors （signet ring cell carcinoma, gland carcinoma, mucous adenocarcinoma）, which from digestive tract. Methods Patients with ovarian metastases from digestive tract which were treated in the Second Hospital of Ji-lin University from Jan. 2009 to Aug. 2012 were retrospectively collected. A total of 46 cases were identi- fied and pathological types were signet ring cell carcinoma（18 cases）,gland carcinoma（16 cases）,mucous adenocarcino- ma（12 cases）. The pathological and clinical features were evaluated. Results All patients with an average age of 50 years old （23 - 91）. 35 cases （76.1%） patients found the primary focal of digestive tract,including 17 cases （48.6% ） from stomach,18 cases （51.4%） from colorectal. Signet ring cell carcinoma were largely originated from the stomach （93.8%）, adenocarcinoma and mucous adenocarcinoma＇ s primary focal is located in colorectal （89.4%） mostly, both of which have statistical significance （P= 0. 000）. Tumor of both ovaries was found in 31 cases, accounting for 67.4 （31/46） ,there were 16 cases （88.9%） ,7 cases （43.8%） ,8 cases （66.7%） respectively ,there is statistically significant between signet ring cell carcinoma and adenocarcinoma （P=0. 000）. Of the three types CK7 were expressed posi- tively in 7 cases （ 7/8,87.5%）, 2 cases （ 2/9,22.2 0% ）, 7 cases （ 7/11,63.60% ） respectively, overall comparison have sta- tistical significance （P=0. 022）,.there is statistical significance between signet ring cell carcinoma and adenocarcinoma （P= 0. 015）. There were 7 cases （87.5%）,2 cases （22.2%）,5 cases （45.5%） expressed CK7（＋）/CK20（A-） re- spectively,overall comparison have statistical significance （P= 0. 037）, there is statistical significance between signet ring cell carcinoma and adenocarcinoma （P= 0.015）, and between signet ring cell carcinoma and （adenocarcinoma＋ mu- cous adenocarcinoma） （P （66.7%）,and 4 cases （36 0. 033）. CK7（-）/CK20（＋） in three types is expressed in 1 case （12. 5%）, 6 cases 4$） respectively, there is no statistical significance overall comparison （P = 0. 079）.Conclusion Signet ring cell carcinoma is more from stomach, more expressed CK7 （＋）/CK20 （＋）, and more bilateral. Adenocarcinoma is more from colorectal and more expressed CK7（-）/CK20（＋）. Mucous adenocarcinoma is more from colorectal.
出处
《中国实验诊断学》
2013年第3期511-515,共5页
Chinese Journal of Laboratory Diagnosis
关键词
消化道
卵巢转移性肿瘤
印戒细胞癌
腺癌
粘液性腺癌
digestive tract
metastatic ovarian tumors
signet ring cell carcinoma
gland carcinoma
mucous adenocar- cinoma
