摘要
目的研究乳腺癌间质T细胞亚群与患者5 a生存率及临床病理特征的关系。方法采用免疫组化方法检测80例乳腺浸润性导管癌间质中CD4+、CD8+T细胞和Foxp3+调节性T细胞(Foxp3+Treg)的表达。结果乳腺癌间质中T细胞亚群的表达与患者5 a生存率无相关性(P>0.05);乳腺癌间质中Foxp3+Treg的浸润与pTNM分期、组织学分级、淋巴结转移呈正相关(P<0.05),与年龄、肿瘤大小无显著性差异(P>0.05);乳腺癌间质中CD4+和CD8+T细胞的浸润与pTNM分期、组织学分级、淋巴结转移呈负相关(P<0.05),与年龄、肿瘤大小无显著性差异(P>0.05)。结论乳腺癌间质Foxp3+T细胞可抑制CD4+和CD8+T细胞的表达,打破肿瘤间质免疫平衡状态,对癌细胞免疫逃逸和肿瘤的侵袭、转移有积极作用。
Objective To analyze the relationship between tumor infiltrating T cell subsets with the 5- year-survival rate and clinicopathologieal features of the patients with breast cancer. Methods The expression of CD4 ＋, CD8 ＋ T cells and Foxp3 ＋ regulatory T cells （Foxp3 ＋ Treg） were detected by immunohistochemistry in 80 cases of breast carcinoma. Results There were no correlation between the expression of tumor infiltrating T cell subsets and the 5-year-survival rate of the patients with breast cancer（P 〉 0.05 ）. Tumor infiltrating Foxp3 ＋ Tregs in the breast cancer mesenchyma was positively correlated to lymph node metastasis, histological grading, pTNM staging （P 〈 0.05 ） , and had no correlation with age and the diameter of tumor. Tumor infiltrating CD4 ＋ T and CD8 ＋ T cells were negatively correlated to lymph node metastasis, histological grading, pTNM staging（P 〈 0.05） , and had no correlation with age and the diameter of tumor. Conclusion Tumor infiltrating Foxp3 ＋ Tregs in the breast cancer mesenchyma can inhibit the expression of CD4 ＋ and CD8 ＋ T cells, alter the immune equilibrium of breast cancer stromal, and contribute to tumor invasion.
出处
《河南科技大学学报（医学版）》
2013年第1期12-15,共4页
Journal of Henan University of Science & Technology:Medical Science
关键词
乳腺癌
间质T细胞亚群
5
a生存率
breast cancer
tumor infiltrating T cell subset
5-year-survival rate
