摘要
目的:观察牙周非手术治疗对冠心病伴牙周炎患者牙周状况、血清白细胞介素-6(interleukin 6,IL-6)及高敏C反应蛋白(high-sensitivity C reactive protein,hs-CRP)的影响,探讨其可能的影响机制。方法:选取冠心病合并中、重度慢性牙周炎的患者(CHD组)50例、单纯中、重度慢性牙周炎患者(CP组)40例、冠心病病人(C组)35例及健康者(H组)50例,对CHD组和CP组实施牙周非手术治疗,进行基线及治疗后1、3个月的临床牙周检查并采集血清;采用酶联免疫吸附法测定血清IL-6及hs-CRP。结果:基线时血清IL-6及hs-CRP在CHD组、CP组、C组高于H组,差异有统计学意义(P<0.05);CHD组和CP组的牙周临床指标显著高于H组和C组(P<0.05);CHD组和CP组经过治疗后所有病人的牙周临床指标、血清IL-6和hs-CRP水平均明显降低(P<0.05)。结论:牙周非手术治疗可改善局部炎症状态,降低冠心病伴牙周炎患者血清中IL-6及hs-CRP水平,有利于冠心病的预防和治疗。
Objective： To evaluate the effect of non-surgical periodontal therapy on periodontal status, the level of serum interleukin-6（IL-6） and high sensitive C-reactive protein （hs-CRP） in coronary heart disease patients with chronic periodontitis. Methods： 50 patients were coronary heart disease and chronic periodontitis（CHD group）. 40 patients were with chronic periodontitis（CP group）. The two groups received non-surgical periodontal therapy. Blood samples were taken for measurement before and after periodontal therapy. 50 healthy controls（H group） and 35patients with coronary heart disease（C group） were detected and were taken samples. IL-6 and hs-CRP were measured by sensitive enzyme-linked immunosorbent assay. Results： The basic concentration of IL-6 and hs-CRP in serum in CHD group, CP group and C group were significantly higher than in H group （P〈0.05） . After periodontal treatment, all patients in CHD group and CP group demonstrated significant improvement in clinically periodontal index （P〈0.05） and the level of IL-6 and hs-CRP in serum（P〈0.05）. Conclusion： This study provided that non-surgical periodontal therapy could decrease the level of the systemic inflammatory markers such as IL-6 and hs-CRP in patients.
出处
《口腔医学研究》
CAS
CSCD
2013年第3期244-247,共4页
Journal of Oral Science Research
基金
"十一五"国家科技支撑计划课题(编号:2007BAI18B02)
辽宁省科学技术计划项目(编号:2007225007)
关键词
牙周炎
冠心病
白细胞介素6
高敏C反应蛋白
Periodontitis Coronary heart disease Interleukin 6 High--sensitivity C reactive protein
