摘要
目的探讨伴腔隙性脑梗死的白质疏松症患者与颅内外大动脉狭窄的相关性。方法选择2012年1月至2012年10月在北京军区总医院神经内科就诊的100例经磁共振成像检查确诊的腔隙性脑梗死合并白质疏松患者为病例组,同期收集100例腔隙性脑梗死不合并白质疏松患者为对照组,按照病例-对照研究设计对所有研究对象行头颈动脉CTA或MRA检查,比较颅内白质疏松严重程度与颅内外大动脉狭窄的相关性。结果腔隙性脑梗死合并白质疏松组颅内外大动脉狭窄发生率明显高于腔隙性脑梗死不合并白质疏松组(P<0.05)。伴腔隙性脑梗死的白质疏松的严重程度与颅内外大动脉狭窄的程度呈正相关。多因素Logistic回归分析显示,高血压、高龄、动脉粥样硬化及狭窄是白质疏松发生的独立危险因素(OR=3.56,95%CI为1.40～9.07;OR=1.56,95%CI为1.04～2.34;OR=2.13,95%CI为1.05～4.31)。结论脑白质疏松症的严重程度与颅内外大动脉狭窄有关。
Aim To investigate the correlation of lacunar infarction with leukoaraisis and intracranial and extracranial artery stenosis. Methods 200 patients who admitted in the Department of Neurology,Beijing Military General Hospital from January 2012 to October 2012 were divided into lacunar infarction with leukoaraiosis group （n100） and lacunar infarction with non-Leukoaraiosis group （n100） according to their cerebral MRI findings, all of them were examined by head/neck CTA/MRA and it was determined whether leukoaraiosis is associated with intracranial or extracranial artery stenosis in patients with leukoaraiosis. Results The incidence rate of extracranial or intracranial artery stenosis in lacunar infarction with leukoaraiosis group was higher than lacunar infarction with non-leukoaraiosis. Severity of leukoaraiosis in patients with lacunar infarction was associated with extracranial or intracranial artery stenosis. Multiple regression showed age, history of hypertension, and artery plaques/stenosis were the strongest determinants of the leukoaraiosis severity. Conclusion The leukoaraiosis is associated with intracranial and extracranial artery stenosis in patients with lacunar infarction.
出处
《中国动脉硬化杂志》
CAS
CSCD
北大核心
2013年第3期243-246,共4页
Chinese Journal of Arteriosclerosis
基金
国家自然科学基金资助(81070948
81171100)
