摘要
目的总结2型糖尿病（T2DM）合并结直肠癌患者的临床特点，探讨2型糖尿病对结直肠癌的影响。方法采用病例对照的研究方法，选择T2DM合并结直肠癌患者（合并T2DM组）32例，另选择同期住院的单纯结直肠癌患者60例，比较两组患者临床资料和组织学分级、肿瘤大小、临床分期以及有无淋巴结转移等相关病理学指标之间的差异。结果合并T2DM组平均年龄（64．90±8．87）岁，空腹血糖为（8．33±4．66）mmol／L，体质量指数（BMI）为（25．77±3．80）kg／m^2，甘油三酯为（1．71±0．85）mmol／L，均高于单纯结直肠癌组[（54．70±11．62）岁、（5．85±0．88）mmol／L、（23．57±3．64）kg／m^2、（1．33±0．83）mmol／L]，差异均有统计学意义（t值分别为4．324、2．982、2．728、2．045，P均〈0．05）。而总胆固醇、高密度脂蛋白胆固醇以及低密度脂蛋白胆固醇比较差异均无统计学意义（P均〉0．05）。合并T2DM患者与单纯结直肠患者的相关病理学指标间差异均无统计学意义（P均〉0．05）。结论糖尿病与结直肠癌患病存在一定的相关性，糖尿病增加了患结直肠癌的风险，糖尿病患者应早期筛查结直肠，以期早发现、早治疗，改善预后。
Objective To investigate the differences of related clinicopathologic features in colorectal cancer （CRC） patients with or without Type 2 Diabetes Mellitus （T2DM）. Methods Using case-control studies,retrospective analysis of colorectal cancer of 60 patients with colorectal cancer hospitalization and 32 cases of T2DM were taken. The clinical data, histological grade, tumor size, clinical stage and lymph node metastasis pathology indicators conditions of the hospitalized CRC patients with or without type 2 diabetes were compared. Results The average age of the team with hospitalized CRC patients combined with type 2 diabetes is （64. 90 ±8.87） ,fasting blood-glucose is （8.33 ±4. 66） mmol/L. BMI and TG are （25.77 ±3.80） kg/m2 and （ 1.71 ± 0. 85 ） mmol/L which were all higher （ （ 54. 70 ± 11.62 ） , （ 5.85 ± 0. 88 ） mmol/L, （ 23.57 ± 3.64 ） kg/m2, （1.33 ± 0. 83 ） mmol/L） than patients without DM. There were significant differences between two groups （ t = 4. 324, t = 2. 982, t = 2. 728, t = 2. 045, respectively, P 〈 0. 05 ）. However, total cholesterol , high density lipoprotein-cholesterol and low density lipoprotein-eholesterol had no significantly differences with those patients without DM （ P 〉 0. 05 ）. There were no significant differences of elinicopathologic features between CRC patients with and without DM （P 〉 0. 05 ）. Conclusion There is a certain correlation between CRC and DM, DM increases the risk of colorectal cancer so diabetes patients should be early screened for colorectal ,with a view to early detection, treatment and improve the prognosis.
出处
《中国综合临床》
2013年第4期339-342,共4页
Clinical Medicine of China
关键词
结直肠癌
2型糖尿病
血糖
血脂
Colorectal cancer
Type 2 diabetes
Blood sugar
Lipids
