摘要
目的评价三维适形放疗(three dimensional conformal radiotherapy,3DCRT)联合同期化疗与单纯3DCRT食管癌的疗效及不良反应。方法收集68例食管癌患者,3DCRT联合同期化疗38例,单纯3DCRT 30例。处方剂量中位数均为64 Gy。同期化疗方案是顺铂25 mg/m2静脉滴注,每周1次。结果 3DCRT联合同期化疗与单纯3DCRT的1、2、3年局部控制率分别为84.2%、68.4%、54.3%和80.0%、63.3%、46.1%(P>0.05),总生存率分别为78.9%、55.3%、34.0%和70.0%、50.0%、28.9%(P>0.05)。不良反应3～4级恶心、呕吐发生率分别为23.7%和0.0%(P<0.05)。放射性食管炎、放射性肺炎、3～4级白细胞减少的发生率比较差异无统计学意义(P>0.05)。结论 3DCRT同期联合25 mg/m2顺铂每周化疗治疗食管癌与单纯3DCRT比较,局部控制率和生存率无明显提高,不良反应仅恶心、呕吐差异有统计学意义。
Objective To evaluate the clinical efficacy and side effects of three dimensional conformal radiotherapy （3DCRT） combined with concurrent chemotherapy. Methods Sixty-eight patients with esophageal carcinoma were treated, including 38 patients receiving 3DCRT combined with concurrent chemotherapy （RC group） and 30 patients receiving 3DCRT alone （R group）. The median prescription dose of radiotherapy was 64 Gy and the concurrent chemotherapy consisted of 25 mg/m2 eisplatin weekly. Results The 1- ,2-,3-year local control rates of RC group and R group were 84.2% ,68.4% ,54.3% and 80.0% ,63.3% ,46.1% respectively（ P 〉 0.05）. The 1-,2-,3-year overall survival rates of RC group and R group were 78.9% ,55.3% ,34.0% and 70.0% ,50.0% ,28.9% respectively（ P 〉 0.05 ）. The incidence of grade 3 - 4 nausea and vomiting for two groups were 23.7% and 0.0% （ P 〈 0.05 ）. There were no significant differences in other acute toxicities between two groups. Conclusion Compared to 3DCRT alone,3DCRT combined with concurrent chemotherapy has no clinical benefits for patients with esophageal carcinoma.
出处
《实用肿瘤杂志》
CAS
2013年第2期189-192,共4页
Journal of Practical Oncology
关键词
食管肿瘤
放射疗法
放射疗法
适形
方法
食管肿瘤
药物疗法
顺铂
治疗应用
存活率
综合疗法
esophageal neoplasms/radiotherapy
radiotherapy, conformal/methods
esophageal neoplasms/drug therapy
cisplatin/therapeutic use
survival rate
combined modality therapy
