摘要
探讨cagⅡ在胃十二指肠疾病患者幽门螺杆菌（H．pylori）中的检出率及其与H．pylori相关性疾病的关系。方法：H．ylori菌株分离自107例胃十二指肠疾病患者，其中慢性胃炎67例，消化性溃疡34例，胃癌6例。采用聚合酶链反应（PCR）技术，对107株H.pylori菌株cagⅡ中的597bp片段进行扩增。结果：107株H．pylori菌株的cagⅡ阳性检出率为69．2％（74／107），慢性胃炎（64．2％）、消化性溃疡（79．4％）和胃癌（4／6）组的检出率无显著差异（P＞0．05）。结论：cagⅡ在不同胃十二指肠疾病患者感染的H.pylori中均有检出，其分布与不同H．pylori相关性疾病的关系并不十分密切，cagⅡ在H．pylori致病中的意义还有待进一步研究。
Background/Aims: To investigate the distribution of cag Ⅱ in Helicobacter pylori (H. pylori) iso-lated from patients with gastroduodenal diseases, and its relationship with H. pylori associated diseases. Methods: 597 bp fragment of cag Ⅱ was amplified by polymerase chain reaction (PCR) in 107 H. pylori strains from 67 patients of chronic gastritis, 34 peptic ulcer, and 6 gastric carcinoma. Results:cag Ⅱ was positive in 74 strains (69.2%), in which 43 (64.2%) came from patients with chronic gastritis,27 (79.4%) from peptic ulcer and 4 (4/6) from gastric carcinoma. Conclusions: cag Ⅱ was distributed in most of H. pylori strains from patients with gastroduodenal diseases. No data regarding the relation ship between existence of cag Ⅱ and occurrence of H. pylori associated diseases have been found.
出处
《胃肠病学》
2000年第2期83-85,共3页
Chinese Journal of Gastroenterology
基金
国家自然科学基金!39670648
欧共体委员会科学基金!IC18CT95-0024
关键词
幽门螺杆菌
感染
基因
毒力
胃肠疾病
Helicobacter pylori Helicobacter Infections Genes
Bacterial Virulence Gastrointestinal Diseases Polymerase Chain Reaction
