期刊文献+

急性心肌梗死患者入院即刻血糖与冠脉病变及预后的相关性研究 被引量:4

Study on the Correlation of Instant Blood Glucose on Admission with Coronary Artery Lesion and Prognosis in Patients with Acute Myocardial Infarction
在线阅读 下载PDF
导出
摘要 【目的】探讨急性心肌梗死(AMI)患者入院即刻血糖水平与冠脉病变及院内主要不良血管事件(MACE)的相关性。【方法】2010年1月至2011年6月就诊于北京友谊医院、并行冠脉造影检查的353例AMI患者,其中单支病变组76例、双支病变组13l例、三支病变组146例,比较不同冠脉病变程度患者入院即刻血糖水平差异,分析其相关性。并根据入院即刻血糖将患者分为正常血糖组184例(血糖〈7.8mmol/L)与高血糖组169例(血糖≥7.8mmol/L),比较不同血糖水平与院内MACE的差异。【结果】双支病变组及三支病变组血糖水平较单支病变组血糖明显升高(P〈0.05),而双支组与三支组血糖水平无统计学差异(P〉0.05)。高血糖组与正常血糖组患者院内MACE发生率分别为11.2%和3.3%,二者比较差异显著(P〈0.05)。【结论】AMI患者的入院即刻血糖水平与冠脉病变严重程度相关,入院即刻血糖是院内MACE的影响因素。 [Objective] To explore the correlation of instant blood glucose on admission with corondry artery le- sion and main adverse cardiac events(MACE) in hospital in patients with acute myocardial infarction(AMI). [Meth- ods] A total of 353 AMI patients undergoing coronary angiography in Beijing friendship hospital from Jan. 2010 to June 2011 were enrolled consecutively and divided into single-vessel lesion group( n = 76), double-vessel lesion group ( n = 131) and three-vessel lesion group( n = 146). Instant blood glucose on admission in patients with different cor- onary lesions was compared. The correlation was analyzed. According to instant blood glucose on admission, all pa- tients were divided into normal glucose group( n = 184, G7.8mmol/L) and hyperglycemia group( n = 169, ≥7.8 mmol/L). Different glucose level and MACE in hospital were compared. [Results] Compared with single-vessel lesion group, blood glucose in double- and three-vessel lesion groups obviously increased( P G0.05), while there was no significant difference between double-vessel lesion group and three-vessel lesion group(P〉0.05). The incidence of MACE in hyperglycemia group and normal glucose group was 11.2% and 3.3%, respectively, and there was signifi- cant difference between two groups( P 〈0.05). [Conclusion] The level of instant blood glucose on admission in AM1 patients is related with the severity of coronary artery lesion. Instant blood glucose on admission is the influencing fac- tor of MACE in hospital.
出处 《医学临床研究》 CAS 2013年第3期497-499,502,共4页 Journal of Clinical Research
关键词 心肌梗死 血糖 分析 冠状动脉疾病 预后 Myocardial Infarction Blood Glucose/ANl Coronary Artery Disease Prognosis
  • 相关文献

参考文献12

  • 1Rasoul S, Ottervanger JP, Timmer JR, et al . Impact of dia- betes on outcome in patients with non ST-elevation myocardi- al infarction[J]. Fur J Intern Med ,2011,22(1) : 89-92.
  • 2Nurkalem Z, Hasdemir H, Ergelen M, et al . The relation- ship between glucose tolerance and severity of coronary artery disease using the Gensini score[J]. Angiology , 2010,61(8) : 751-755.
  • 3The Emerging Risk Factors Collaboration. Diabetes mellitus, fasting blood glucose concentration, and risk of vascular dis- ease: a collaborative meta-analysis of 102 prospective studies [J]. Lancet ,2010, 375(9733): 2215 - 2222.
  • 4Mette L N, Charlotte A, Peter RH, et al . Temporal trends in the initiation of glucose-lowering medications after a first- time myocardial infarction-a nationwide study between 1997 and 2006[J]. Cardiovasc Diabetol ,2011,10: 5-12.
  • 5Yang ZQ, Laubach VE, French BA, et al . Acute hypergly cemia enhances oxidative stress and exacerbates myocardial in farction by activating NADPH oxidase during reperfusion[J]. J Thorac Cardiovasc Surg ,2009,137(3): 723-729.
  • 6Gissette RS, Steve H, Marco RD, et al . Endothelial function in individuals with coronary artery disease with and without type 2 diabetes[J]. Metabolism ,2010,59(9): 1365-1371.
  • 7()liver MF. Metabolic causes and prevention of ventricular fi brillation during acute coronary syndromes[J]. Am J Med , 2002,112(4) =305-311.
  • 8Gresele P, Guglielmini G, De Angeiis M, et al. Acute, short-term hyperglycemia enhances shear stress-induced platelet activation in patients with type H diabetes mellitus [J]. J Am Coll Cardiol ,2003,41(6) :1013-1020.
  • 9Aliada A, Friedman J, Ghanim H, et al . Glucose ingestion induces an increase in intranuclear nuclear factor kappa B, a fall in cellular inhibitor kappa IS, and an increase in tumor necrosis factor alpha messenger RNA by mononuclear cells in healthy human subjects[J:. Metabolism , 2006,55 (9) : 1177-1185.
  • 10Yang SW, Zhou YJ, Nie XM, et al . Effect of abnormal fast ing plasma glucose level on all-cause mortality in older pa tients with acute myocardial infarction: results from the bei jing elderly acute myocardial infarction study (BEAMIS)[J]. Mayo Clin Proc ,2011,86(2) :94-104.

同被引文献30

引证文献4

二级引证文献27

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部