摘要
目的比较阿立哌唑与喹硫平治疗男性精神分裂症的疗效及不良反应。方法将100例男性精神分裂症患者随机分为阿立哌唑组和喹硫平组,各50例,治疗时间均为8周。采用PANSS评定疗效,锥体外系副反应量表(RSESE)评定不良反应。结果治疗8周后,阿立哌唑组有效率为94.00%,喹硫平组有效率为92.00%,两组疗效比较差异无统计学意义(P>0.05)。阿立哌唑组的不良反应总发生率显著地少于喹硫平组(P<0.05)。结论阿立哌唑与喹硫平治疗男性精神分裂症疗效相当,不良反应阿立哌唑更轻。
Objective To compare the effects of aripiprazole and quetiapine in the treatment of male schizophrenia patients on the efficacy. Methods One hundred male schizophrenia patients were randomly divided into the aripiprazole group （n=50） and quetiapine group （n=50）, which were treaded with aripiprazole or quetiapine for 8 weeks, respectively. The clinical efficacy was evaluated by PANSS and the adverse reactions were evaluated by RSESE. Results At the end of the eighth week, the effective rates of the aripiprazole group and the quetiapine group were 94.00% and 92.00% , respectively, with no statistically significant difference between the two groups. The incidence of adverse reactions in the aripiprazole group was significantly lower than that in the quetiapine group. Conclusion Aripiprazole is as effective as quetiapine in the treatment of male schizophrenia patients, and aripiprazole results in fewer adverse effects.
出处
《海南医学》
CAS
2013年第7期951-953,共3页
Hainan Medical Journal
