摘要
目的探讨咪达唑仑联合丙泊酚麻醉在结肠癌根治术中的应用及其对患者应激反应的影响，以期探索新的临床麻醉药物合理配伍。方法选择接受结肠癌根治术治疗的患者40例，平均随机分为对照组与联合组，对照组采用丙泊酚进行麻醉诱导及维持，联合组则在对照组基础上在麻醉诱导时加用咪达唑仑。观察并比较两组患者在麻醉诱导前（T1）、手术开始后4h（T2）以及手术结束后24h（13）时血糖、C-反应蛋白（CRP）、皮质醇以及补体C3的变化情况。结果与T1相比，所有患者血糖在手术开始后4h及结束后24h均显著升高（均P〈0．05）；与联合组相比，对照组以上指标变化更为显著（P〈0．05）；两组患者CRP及皮质醇水平均较T1显著升高（P〈0．05），以对照组更为显著（P〈0．05）；补体C3则呈现先降低后升高的显著趋势（P〈0．05），对照组在T2时降低最为显著（P〈0．05）。结论咪达唑仑联合丙泊酚可显著抑制结肠癌根治术时应激反应强度。
Objective To explore the influence of combination anaesthesia application of midazolam and propofol on stress reactions in radical resection of colon cancer, and to explore novel clinical compatibility of anaesthesia drugs. Methods 40 patients received radical resection of colon cancer were selected and divided into control group and combination group randomly and evenly. Control group received general anesthesia by propofol, while combination group received additional midazolam when anesthesia induction was taken. Glycemia, CRP, complement C3 and cortisol were observed and compared at T1 （before anesthesia induction） ,T2 （4h after beginning of surgery） and T3 （ 24h after surgery）. Results Compared with T1, glu increased significantly at T2 and T3 （ all P 〈 0.05 ） ; Compared with combination group, glycemia increased more significant in control group （ P 〈 0.05 ） ; CRP and cortisol increased significantly in all patients compared with T1 （P 〈 0.05 ）, more significant in control group （P 〈 0.05 ） ;a significant decrease after increase trend was identified for complement C3 （ P 〈 0.05 ） , more significant decrease was found in control group at T2 （ P 〈 0.05 ）. Conclusion Combination anesthesia of propofol and midazolam could decrease the strength of stress reaction in radical resection of colon cancer.
出处
《中国基层医药》
CAS
2013年第8期1186-1188,共3页
Chinese Journal of Primary Medicine and Pharmacy
关键词
麻醉
咪达唑仑
丙泊酚
应激反应
Anesthesia
Midazolam
Propofol
Stress Reaction
