摘要
目的探讨妊娠期高血压疾病、妊娠期糖尿病、妊娠合并血小板减少症时,母血中胎儿有核红细胞(fetal nucleated red blood cell,FNRBC)数量的变化。方法选择临床确诊的妊娠期高血压疾病患者30例(其中子痫前期轻度12例,子痫前期重度12例,子痫6例),妊娠期糖尿病患者23例(其中血糖控制理想无低血糖或酮症发生13例,血糖控制不理想曾发生低血糖或酮症10例),妊娠合并血小板减少患者18例,另外选择20例正常孕妇作为对照,分别取外周血进行单密度梯度离心、瑞氏-姬姆萨染色和细胞计数。结果妊娠期高血压疾病子痫前期轻度、子痫前期重度和发生子痫患者母血中FNRBC数量与对照组比较差异均有统计学意义(P<0.05);且子痫前期轻度、重度和发生子痫患者母血中FNRBC数量之间比较差异均有统计学意义(P<0.05)。妊娠期糖尿病患者母血中FNRBC数量与对照组比较差异有统计学意义(P<0.05);血糖控制理想不伴低血糖或酮症发生患者母血中FNRBC数量与血糖控制不理想伴低血糖或酮症发生的患者比较差异有统计学意义(P<0.05)。妊娠合并血小板减少患者母血中FNRBC数量与对照组比较差异无统计学意义(P>0.05)。结论妊娠期高血压疾病子痫前期和发生子痫患者以及妊娠期糖尿病患者母血中FNRBC数量增加,而且患者病情加重,母血中FNRBC数量增加更明显。提示母血中FNRBC数量增加预示妊娠并发症程度加重并威胁胎儿生命,应积极采取干预措施,必要时终止妊娠。
Objective To investigate the changes of fetal nucleated red blood cells count （FNRBC） in peripheral blood of pregnant women with different pregnancy complications, such as hypertensive disorders in pregnancy, gestational diabetes mellitus （GDM） and pregnancy with thrombocytopenia. Methods Thirty clinically diagnosed hypertensive disorders in pregnancy patients （ 12 cases mild preeclampsia, 12 cases severe preeclampsia, 6 cases eelampsia）, 23 cases GDM patients （ 13 cases blood sugar control ideal and without hypoglycemia or ketosis, 10 cases whose blood sugar control was not ideal and ever occurred hypoglycemia or ketosis） and 18 cases pregnancy with thrombocytopenia patients were analyzed in this study. Twenty cases normal pregnant women were taken as control at the same time. The peripheral blood of women in each group was obtained to count FNBRC and perform Wright-Giemsa stain after single density gradient centrifugation. Results There were significant differences in FNRBC number in peripheral blood of mild preeclampsia patients, severe preeclampsia patients and eclampsia patients compared with normal pregnant women in control group （ P 〈 0.05 ）.
出处
《河北医科大学学报》
CAS
2013年第3期280-283,共4页
Journal of Hebei Medical University
关键词
妊娠并发症
红细胞
孕妇
pregnancy complications
erythrocytes
pregnant women
