摘要
目的应用相干光断层扫描(OCT)分析特发性脱髓鞘性视神经炎(IDON)所致视神经萎缩眼的视网膜神经纤维层厚度(RNFLT)和黄斑厚度(MT)的变化及其与病程和最佳矫正视力(BCVA)的相关性。设计回顾性病例系列。研究对象眼底表现视盘色苍白确定为视神经萎缩的IDON患者16例(16眼)及性别年龄匹配的健康对照23例(23眼)。方法回顾OCT和BCVA检查结果,对比分析两组RNFLT和MT的差异,平均RNFLT和黄斑容积平均厚度的关系以及RNFLT和MT与病程和BCVA的线性相关关系。主要指标平均(360°)RNFLT、四个象限RNFLT、黄斑容积平均厚度、ETDRS栅格9个分区的MT、病程及BC-VA。结果与正常对照相比,病例组360°平均和四个象限RNFLT均显著变薄(P均=0.00),除中心子区外(P=0.25),其余分区MT和黄斑容积平均厚度均显著变薄(P均=0.00)。平均RNFLT与黄斑容积平均厚度存在直线相关关系(r=0.662,P=0.01),平均RNFLT和黄斑容积平均厚度与病程均无直线相关关系(P=0.70,P=0.13)。平均RNFLT和黄斑容积平均厚度与BCVA均无直线相关关系(P=0.80,P=0.28)。结论有视神经萎缩的IDON患者除黄斑中心子区MT无显著变化外,其余分区MT和所有象限RNFLT均显著变薄,黄斑容积平均厚度与平均RNFLT存在线性相关关系,RNFLT越薄黄斑容积平均厚度越薄。RNFLT和黄斑容积平均厚度与病程和BCVA无线性相关关系。
Objective To analyze retinal nerve fiber layer thickness （RNFLT） and macular thickness （MT） using optical coherence tomography （OCT） in eyes with optic atrophy following idiopathic demyelinating optic neuritis （IDON） and to evaluate the relationship between RNFLT, MT, disease duration and best corrected visual acuity （BCVA）. Design Retrospective case series. Participants Sixteen eyes with optic atrophy from 16 IDON patients and 23 normal eyes from 23 age and sex-matched healthy controls. Methods All partici- pants underwent optical coherence tomography （OCT） and BCVA examinations. The difference between the two groups, and the linear relationship between average （360°） RNFLT, cube average MT, disease duration and BCVA were evaluated. Main Outcome Measures Average RNFLT, RNFLT in the four quadrants, cube average MT, MT of 9 ETDRS sub-areas, disease duration and BCVA. Results Except for the central sub-area MT, all MT and RNFLT of optic atrophy eyes in IDON patients showed significant reduction （P=0.00）. Cube average MT had a linear relationship with average RNFLT （r=0.662, P=0.01）. Both average RNFLT and cube average MT had no linear relationship with disease duration （P=0.70,P=0.13）. Both average RNFLT and cube average MT had no linear relationship with BCVA （P=O.g0,P=0.28）. Conclusions Except for the central sub-area MT, all MT and RNFLT measurements of optic atrophy eyes in IDON patients showed a significant reduction. Cube average MT had a linear relationship with average RNFLT and was dependent on RNFLT. Both average RNFLT and cube average MT had no linear relationship with disease duration or BCVA.
出处
《眼科》
CAS
2013年第2期130-134,共5页
Ophthalmology in China
基金
"十二五"国家科技支撑计划视神经炎的临床研究(2012BAI08B06)
