摘要
目的评价256层螺旋CT联合高敏C反应蛋白(hs-CRP)和脂联素(adiponectin,APN)检测对急性冠脉综合征(ACS)患者易损斑块的临床价值。方法入选2011年6月至2012年6月内蒙古民族大学附属医院心血管内科收治的60例冠心病患者,其中ACS组30例,稳定型心绞痛组(SAP)30例,进行256层螺旋CT冠状动脉成像,对冠状动脉内斑块进行评价。同时检测患者hs-CRP及APN浓度,并进行选择性冠状动脉造影检查。另选冠脉造影正常对照组22例。结果①ACS组软斑块发生率明显高于SAP组,差异有统计学意义(P<0.01)。②与对照组比较ACS组、SAP组hs-CRP浓度明显升高,差异有统计学意义(P<0.01),且ACS组较SAP组升高更明显,差异有统计学意义(P<0.05);APN水平明显降低,差异有统计学意义(P<0.01),且ACS组较SAP组降低更明显,差异有统计学意义(P<0.05)。③冠心病患者软斑块组与纤维斑块、钙化斑块组比较hs-CRP浓度明显升高,差异有统计学意义(P<0.05);APN水平明显降低,差异有统计学意义(P<0.05)。结论 256层螺旋CT冠状动脉斑块检查联合hs-CRP和APN检测更有益于判断斑块的稳定性,可作为冠状动脉斑块不稳定性的预测指标,有助于ACS的早期诊断。
Objective To evaluate the clinical value of 256-slice spiral computed tomography combined hs-CRP and APN to detect the vulnerable plaque of acute coronary syndrome patients. Methods Selected 60 cases of patients with coronary heart disease, 30 cases of which ACS group, 30 cases stable angina group（SAP）in all patients underwent 256-slice spiral computed tomography Coronary artery imaging.Then we detected the concentration of hs-CRP andAPN.And then all patients underwent selective coronary angiography.Another 22 cases in the control group. Results ①Soft plaque incidence of ACS group was significantly higher than SAP, the difference was statistically significant（P0.01）. （2）Compared with the control group, hs-CRP serum levels of ACS group and SAP group were significantly increased, the difference was statistically significant（P0.01）, and the ACS group was higher than SAP group（P0.05）. APN serum levels of ACS group and SAP group were significantly decreased, the difference was statistically significant（P0.01）, and the ACS group was lower than SAP group（P0·05）. （3）In CHD patients,Compared with the fibrous plaque, calcified plaque group, hs-CRP serum levels of soft group was significantly increased（P0.05）and APN serum levels were significantly decreased, the difference was statistically significant（P0.05）.Conclusion The detection of 256-slice spiral computed tomography combined hs-CRP and APN can assess stability of the plaque, raise the accuracy of coronary artery plaque in patients with ACS and improve the diagnosis rate of ACS.
出处
《中国实用医药》
2013年第7期17-19,共3页
China Practical Medicine
关键词
256层螺旋CT
高敏C反应蛋白
脂联素
急性冠脉综合征
易损斑块
256-slice spiral computed tomography
High sensitivity C-reactive protein
Adiponectin
acute coronary syndrome
Vulnerable plaque
