摘要
目的血糖控制不理想的2型糖尿病患者将胰岛素治疗时3次预混胰岛素方案与三短一中方案的临床运用对比。方法患者随机分为2组,A组100例,三餐前半小时皮下注射甘舒霖30R或50R(以空腹血糖高为主使用甘舒霖30R,以餐后血糖高为主使用甘舒霖50R);B组102例,三餐前半小时皮下注射甘舒霖R及睡前注射甘舒霖N,根据血糖情况调整胰岛素剂量以达目标血糖值。观察达目标血糖值时间、糖化血红蛋白、患者依从性、低血糖发生率。结果三短一中较3次预混胰岛素治疗,虽达目标血糖值时间短,但两者比较差异无统计学意义;在低血糖发生率、依从性方面、糖化血红蛋白方面的比较中,3次预混胰岛素治疗疗效均优于三短一中的治疗。结论对于血糖控制不理想的2型糖尿病患者使用每日3次皮下注射胰岛素治疗较三短一中方案更易被患者接受及坚持,从而实现其血糖长期有效的达目标血糖,以减少糖尿病急慢性并发症。
Objective To suboptimal glycemic control in type 2 diabetes patients with insulin treatment three premixed insulin regimen and three short in a programme of clinical application of contrast.Methods Patients were randomly divided into 2 groups,100 cases in group A,half an hour before meals to subcutaneous injection of Ganshulin 30R or 50R（with high fasting blood glucose mainly using Ganshulin 30R,to postprandial glucose high mainly using Ganshulin 50R）;102cases in group B,half an hour before meals to subcutaneous injection of Ganshulin R and Ganshulin N bedtime injection ,based on blood glucose level adjustment of the insulin dose to achieve target blood glucose value.Observation of the target blood glucose value time,glycosylated hemoglobin,patient compliance,the rate of hypoglycemia.Results Three short and one middle to three times of premixed insulin treatment,although up to a target blood glucose value time is short,but both were not significantly different;in the incidence of hypoglycemia,compliance,glycosylated hemoglobin in the comparison,the three premixed insulin treatment were better than three short in the treatment of.Conclusion For suboptimal glycemic control in type 2 diabetic patients with the use of 3 daily subcutaneous injection of insulin in treatment of a three short programmes more easily accepted by the patient and adhere to,in order to achieve its long-term effective as target blood glucose,to reduce the acute and chronic complications of diabetes.
出处
《中国冶金工业医学杂志》
2013年第2期136-137,共2页
Chinese Medical Journal of Metallurgical industry
