摘要
考察L 门冬酰胺酶前体脂质体 (L ASNasePL)与L ASNase对移植性小鼠急性淋巴细胞白血病的作用。采用DBA/ 2小鼠两种L12 10 、P3 88腹水瘤模型 ,脂质体组和L ASNase组小鼠每天ip一次 (按L 门冬酰胺酶计 740 0 ,370 0 ,185 0KU/kg) ,连续 10d。设生理盐水组 (0 9%NaCl,0 4ml/ 2 0 g)及阿霉素注射剂 (2mg/kg)组为阴性和阳性对照组。结果L ASNasePL及L 门冬酰胺酶 (L ASNase)皆能显著延长移植性淋巴细胞白血病的小鼠存活天数 (P <0 0 1) ,L ASNasePL对L12 10 、P3 88移植小鼠 ,生命延长率分别最高达 184 7%和 183 3%。L ASNase组生命延长率最高分别为 132 9%和 132 1%。L ASNasePL与相同剂量的L ASNase相比 ,其高、中剂量组 (740 0 ,370 0kU/kg)皆显著延长L12 10 、P3 88小鼠的存活天数 (P <0 0 5 )。
OBJECTIVE:To examine the effect of L Asparaginase proliposomes(L ASNasePL)and L Asparaginase(L ASNase)on acute lymphatic leukaemia in mice METHODS: The dose of L ASNasePL and L ASNase group mice(7 400,3 700,1850kU/kg)was given ip one time every day for 10 days adopting L 1210 and P 388 acute tumor model Saline and Doxorubicin used as negative and positive control RESULTS: L ASNasePL and L ASNase could extend acute lymphatic leukaemia mice survival time significantly( P <0 01) The life lengthen ratio of L ASNasePL was the highest to 184 7% in L 1210 group and 183 3% in P 388 group respectively, and that of L ASNase was the highest to 132 9% in L 1210 group and 132 1% in P 388 group respectively CONCLUSION: Compared with the same dose of L ASNase ,the high and middle dose (7400,3700KU/kg)L ASNasePL extend survival time of L 1210 and P 388 mice( P <0 05)
出处
《药物生物技术》
CAS
CSCD
2000年第1期19-22,共4页
Pharmaceutical Biotechnology
基金
江苏省社会发展基金 !BS970 71
