摘要
目的:观察运用"证素辨证"原理,对慢性肾衰竭(CRF)患者进行证素(即病位及病性)演变的情况研究。方法:收集CRF(慢性肾脏病CKD 2～CKD 5期)患者141例,对照无肾功能下降的CKD 1期22例,研究主要病位、病性,分析各期病位、病性的主次,研究各证素随分期进展的变化特点。结果:本病病位以肾、脾、肝、胃、肺等为主,病性以气虚、阳虚、湿、血虚、阴虚等为主;各病位、病性积分程度存在随分期进展递增的趋势。结论:本病病机为脾肾衰败、气血阴阳不足,湿热瘀毒内蕴,气机逆乱,而疾病后期,病邪入络,癥瘕内留;病理变化逐级加重,而初期湿邪为重,虚证亦显;中期虚实均加重,虚证更显;后期脾肾衰败,虚实并重。
Objective ：To study the changes in syndrome elements （location and nature of disease） among pa- tients with chronic renal failure （CRF） based on the principle of ＂syndrome element differentiation＂. Methods：Atotal of 141 CRF patients with stage 2 -5 chronic kidney disease （CKD） were included in the study, and 22 pa- tients with stage 1 CKD who had no decline in renal function were used as controls. The location and nature of dis- ease were investigated, and the primary location and nature of disease in each stage were analyzed. The characteris- tics of change in eaeh syndrome element with the progression of disease were studied. Results ： In these patients, the primary locations of disease were the kidney, spleen, liver, stomach, and lung, and the primary natures of disease were qi deficiency, yang deficiency, dampness, blood deficiency, and yin deficiency. The total scores of eaeh location or nature of disease rose as the stage increased. Conclusion： The pathogenesis of CRF includes spleen and kidney failure, deficiency of qi,blood, yin, and yang, accumulated dampness - heat and toxin, and qi - movement disturb- anee. In late stage of this disease,the pathogenic factors invade the collaterals and abdominal mass is retained;the pathological ehanges increase gradually, and pathogenic dampness is severe and defieieney syndrome also appears in the early stage;defieiency and exeess become severe and deficiency syndrome is more apparent in the middle stage; spleen and kidney failure oeeurs and deficiency and excess are of the same severity in the late stage.
出处
《湖南中医杂志》
2013年第4期18-20,共3页
Hunan Journal of Traditional Chinese Medicine
关键词
证素辨证
慢性肾衰竭
证候
syndrome element differentiation
chronic renal failure
syndrome
