摘要
目的探讨术前化疗对局部晚期食管癌的影响。方法将2006年1月至2008年1月82例临床分期为Ⅲ期的食管癌患者随机分为两组,实验组40例给予顺铂、5-氟尿嘧啶1～2周期术前化疗,对照组42例直接手术。比较两组手术时间、出血量、并发症发生率、根治性切除率及术后1、3年生存率。结果两组手术时间、出血量、并发症发生率的差异无统计学意义。实验组根治性切除率为87.5%,对照组为40.5%,两组间的差异具有统计学意义。实验组1、3年生存率分别为90.0%、52.5%,对照组分别为59.5%、26.2%,两组间的差异具有统计学意义。结论术前1～2周期顺铂+5-氟尿嘧啶化疗能降低局部晚期食管癌的临床分期,提高根治切除率及1、3年生存率,而不增加手术并发症。
Objective To explore the effect of preoperative chemotherapy for locally advanced esophageal carcinoma. Methods Totally 82 cases of esophageal carcinoma in our department from January 2006 to January 2008 were random- ly divided into two groups ,whose preoerative clinical TNM stage were ill ,40 patients of those were treated with neoadju- vant therapy of PF（ DDP 80 mg/m2. dl ;5 - FU 300 mg/ma, dl - 5 ） 1 -2 cycles befor surgery（ group A）, the control group were performed surgery immediately. The operative time, the amount of hemmorrhage, the incidence of complica- tion, the radical resection rate and 1,3 - year survival rate between two groups were compared. Results The difference of the operative time, the amount of hemmorrhage and the incidence of complication between two groups were no statisti- cal significance. The radical resection rate of group A were 87. 5% ,the control group were 40. 5%, there were statistical significance between the two groups. Conclusions New adjuvant chemotherapy with PF 1 - 2 cycles can significantly re- duce the tumor clinical stage of the locally advanced esophageal carcinoma and enhance the resection rate, it is able to in- crease the 1,3 -year survival rate without increase the operative complication.
出处
《医药论坛杂志》
2013年第3期38-39,共2页
Journal of Medical Forum
关键词
食管肿瘤
术前化疗
局部晚期
临床意义
Esophageal neoplasm
Preoperative Chemotherapy
Locally Advanced
