摘要
目的:探讨卵巢上皮性肿瘤组织中P-EphA2的表达及其与临床病理因素的关系。方法:采用免疫组织化学Sp法检测82例卵巢上皮性肿瘤及24例正常卵巢组织中P-EphA2的表达情况。结果:在正常卵巢、卵巢上皮性良性肿瘤和卵巢恶性上皮性肿瘤组织中,P-EphA2蛋白的阳性表达率分别为100%、79.31%、26.9%,差异有统计学意义(P<0.05);卵巢恶性肿瘤中P-EphA2的表达与卵巢恶性上皮性肿瘤FIGO分期有关,差异有统计学意义(P<0.05),而与组织学分级、组织学类型、淋巴结转移、患者年龄无关。结论:P-EphA2与卵巢上皮性肿瘤的良恶性有关,在恶性肿瘤中,P-EphA2的表达显著降低,其表达与卵巢恶性肿瘤的FIGO分期相关。P-EphA2在卵巢上皮性恶性肿瘤中的低表达可以作为卵巢上皮性恶性肿瘤的诊断指标,可能成为新的卵巢癌诊断参考指标之一。
Objective： To investigate the relationship of P-EphA2 expression and clinical pathological character of ovarian epi- thelial neoplasm. Methods ： The positive expressions of P-EphA2 in 82 cases of ovarian epithelial neoplasm and 24 cases of normal ovary tissue were detected using immunohistochemistry. Results： The positive expression rates of P-EphA2 in normal ovary, benign ovarian ep- ithelial neoplasm, and malignant ovarian epithelial neoplasm tissue were 100% ,79.31% ,26. 9%, respectively, and there were statisti- cal differences （ P 〈 0. 05 ）. The expression level of P-EphA2 was correlated with clinical stage of malignant ovarian epithelial neoplasm （ P 〈 0. 05 ）, and was not correlated with histological grade and category, lymph node metastasis and age of patients. Conclusion： P-E- phA2 is related with the malignancy of ovarian epithelial neoplasm, P-EphA2 could be one of the biological indicators of ovarian epithe- lial neoplasm.
出处
《肿瘤预防与治疗》
2013年第2期63-67,共5页
Journal of Cancer Control And Treatment
