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尿白蛋白肌酐比与2型糖尿病患者颈动脉内膜中层厚度的相关性研究 被引量：2

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摘要 目的探讨尿白蛋白肌酐比(UACR)与2型糖尿病患者颈动脉内膜中层厚度(cIMT)的关系和临床意义。方法采用横断面试验设计,纳入316例2型糖尿病患者,留取晨尿标本测定UACR,cIMT采用彩色多普勒超声显像仪进行测量。依据UACR水平将所有患者分为正常白蛋白尿者220例、微量白蛋白尿者64例和大量白蛋白尿者32例。组间比较采用方差分析或卡方检验。采用Pearson相关分析或Spearman相关分析评价cIMT与临床指标的关系,采用多元逐步回归分析确定cIMT的独立影响因素。结果大量白蛋白尿组cIMT〔(0.94±0.25)mm〕高于正常白蛋白尿组〔(0.78±0.17)mm〕(P<0.05),微量白蛋白尿组的cIMT〔(0.89±0.18)mm〕高于正常白蛋白尿组(P<0.05);cIMT与年龄、糖尿病病程、收缩压、UACR呈正相关(P<0.05),与估算肾小球滤过率(eGFR)呈负相关(P<0.05);糖尿病病程和UACR是cIMT的独立影响因素(P<0.01)。结论 UACR是2型糖尿病患者cIMT的独立危险因素,增加动脉粥样硬化的发生风险,应进行早期防治。
作者 邓玲 梁利波 张亭 张明峰 杨惠岚 李双庆
机构地区 四川大学华西医院金卡全科病房 四川大学华西医院内分泌与代谢科
出处 《四川大学学报（医学版）》 CAS CSCD 北大核心 2013年第3期485-488,共4页 Journal of Sichuan University(Medical Sciences)
关键词 尿白蛋白肌酐比 颈动脉内膜中层厚度 2型糖尿病
分类号 R587.1 [医药卫生—内分泌]
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参考文献15

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共引文献169

同被引文献28

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引证文献2

二级引证文献7

四川大学学报（医学版）
2013年 第3期

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