摘要
目的 比较大肠癌术后单用 5 Fu及联合应用 5 Fu、顺铂及丝裂霉素行腹腔化疗 (in traperitonealchemotherapy,IPC)的疗效及并发症。方法 5 2例大肠癌术后分为 5 Fu组 (32例 )及联合组 (2 0例 )。术后 2周行IPC ,比较两组腹腔癌肿复发率 ,种植灶治愈率及毒副作用发生率的差异。结果 ① 5 Fu组的DukesC1期患者腹腔癌肿复发率为 5 8 3% ,显著高于联合组的C1期 (无 1例复发 ) ,P <0 0 1。联合组 5例D期患者 ,3例再次手术证实腹腔内原种植灶全部消失 ;②联合组的粘连性肠梗阻发生率为 2 5 0 %、化学性腹膜炎为 40 0 %及胃肠反应率 5 0 0 % ,均分别显著高于 5 Fu组的3 1% (P <0 0 5 )、9 3 % (P <0 0 5 )及 3 1% (P <0 0 1) ;③两组共 6例粘连性肠梗阻 (5 Fu组 1例 ,联合组 5例 ) ,术中发现其粘连呈腹茧症表现 ,行肠排列术后治愈。结论 联合组的IPC疗效及粘连性肠梗阻发生率均显著高于 5
Objective[WT5”BZ] To evatuale the curative effect and complications of postoperative intraperitoneal chemotherapy (IPC) using 5 Fu only and 5 Fu+PDD+MMC in colorectal cancer patients.[WT5”HZ]Methods[WT5”BZ] 52 cases with colorectal cancer were divided into 5 Fu IPC group (32 cases) and combined IPC group (20 cases).IPC was given two weeks postoperatively.[WT5”HZ]Results[WT5”BZ] ①The incidence of peritoneal recurrence in Dukes C1 phase patients using 5 Fu was 58 3%,significantly higher than that in combined IPC group (no recurrence) P <0 01.Relaparotomy found that the primary peritoneal seeding foci disappeared in 3 of 5 Dukes D cases allocated to combined IPC group.②The incidence of adhesive ileus,chemical peritonitis and vomiting in combined IPC group was 25 0%,40 0% and 50 0%,respectively which were significantly highter than that in 5 Fu group 〔3 1%( P <0 05),9 3%( P <0 05),and 3 1%( P <0 01)〕,respectively.Severe intraabdominal adhision (cocoon) was found in 6 cases(1 in 5 Fu group and 5 in combined group) which necessitated a lysis of the adhesive ileus.[WT5”HZ]Conclusions[WT5”BZ] The curative effect and the incidence of adhesive ileus in combined IPC group were significantly higher than that in 5 Fu group.
出处
《中华普通外科杂志》
CSCD
2000年第7期402-404,共3页
Chinese Journal of General Surgery
