摘要
目的:观察布拉氏酵母菌对小儿抗生素相关性腹泻(AAD)的预防作用。方法:对符合研究的107例住院患儿,随机分为两组,预防组和对照组,预防组在常规治疗的基础上,常规剂量口服布拉氏酵母菌颗粒,比较两组患儿AAD的发生率、腹泻程度、腹泻持续时间。结果用药第3、5、7、14天时,预防组腹泻发生率均低于对照组,差异均有统计学意义(P<0.05、P<0.01);用药7天时两组发生轻度腹泻、重度腹泻、无腹泻的构成差别有显著意义(X2=8.41,P<0.05)。结论:布拉氏酵母菌能安全、有效地预防AAD的发生。
Objective ：To evaluate the effect of applying Saccharomyces boulardii to hospitalized children on preventing the antibiotic -associated diarrhea. Methods： The inpa- tients of 107 cases consistent with standard of our investigations, divided into the pre- vention group and the control group in ran- dom. On the basis of conventional therapy, the prevention group took Saeeharomyces boulardii of routine dosage for oral use. We observed the incidence rate and the time of antibioticassociated diarrhea occurred in two groups. Results ： On the 3rd,5th,7th and 14th days, there were significant differences between the two groups in the incidence rate of AAD（P 〈 0.05 or P 〈 0.01）. Conclusion：If the inpatients who use antibiotics wand take Saccharomyces boulardii,it could prevent the AAD effectually.
关键词
布拉氏酵母菌
抗生素相关性腹泻
预防
Saccharomyces boulardii
Antibiotic - associated diarrhea
Prevention
