摘要
目的探讨第10染色体同源丢失磷酸酶-张力蛋白基因(PTEN)在宫颈癌组织中的表达及对宫颈癌发生、发展的作用。方法选取广东省汕头市中心医院2009年6月～2010年6月宫颈石蜡包埋组织90例,其中正常宫颈组织20例,宫颈癌组织70例;采用SP法检测两类组织中PTEN的表达情况;分析PTEN表达与宫颈癌临床病理指标的关系。结果①PTEN在正常宫颈组织阳性表达率[100%(20/20)]高于在宫颈癌组织中的阳性表达率[70%(49/70)],差异有高度统计学意义(χ2=7.83,P<0.01)。②PTEN在宫颈癌临床分期(Ⅰ、Ⅱ期)中的表达差异无统计学意义(χ2=1.48,P>0.05);PTEN在中高分化和低分化宫颈癌的阳性表达率[71.7%(43/60),60.0%(6/10)]差异无统计学意义(χ2=0.56,P>0.05);PTEN在无淋巴结转移的宫颈癌组织中阳性表达率[73.6%(39/53)]与有淋巴结转移的宫颈癌组织中的阳性表达率[58.8%(10/17)]差异无统计学意义(χ2=1.34,P>0.05)。结论 PTEN蛋白的表达缺失可能与宫颈癌的发生、发展相关。
Objective To discuss the expression of PTEN in occurrence and development of cervical cancer tissue.Methods 90 cases of cervical paraffin embedding tissue in Shantou Center Hospital of Guangdong Province from June 2009 to June 2010 were selected including 20 cases of normal cervical tissue and 70 cases of cervical cancer tissue.SP method was used in the two types of tissue to detect the expression of PTEN;the relationship between the expres sion of PTEN and clinical pathological indicators of cervical cancer.Results ①Positive expression rate in normal cervical tissue [100%（20/20）] was higher than that in cervical cancer tissue [70%（49/70）],the difference was statistically significant（χ2 = 7.83,P 0.01）.②The difference of positive expression rate in different clinical stages（Ⅰ,Ⅱ stage） was not statistically significant（χ2 =1.48,P 0.05）;the difference of positive expression rate in high-middle differentiation and poor differentiation cervical cancer [71.7%（43/60）,60.0%（6/10）] was not statistically significant（χ2 = 0.56,P 0.05）;the difference of positive expression rate in lymph node metastasis [58.8%（10/17）] and nonlymph node metastasis [73.6%（39/53）] was not statistically significant（χ2 = 1.34,P 0.05）.Conclusion The incomplete expression has relationship with occurrence and development of cervical cancer tissue.
出处
《中国医药导报》
CAS
2013年第15期37-39,共3页
China Medical Herald
