摘要
目的探讨炎琥宁注射液联合头孢呋辛钠治疗儿童社区获得性肺炎的临床疗效及安全性。方法选取儿童社区获得性肺炎患儿72例,随机分为治疗组和对照组,每组为36例,两组均给予头孢呋辛钠60～80 mg/kg静脉滴注,1次/d,在此基础上,治疗组加用炎琥宁注射液5～7 mg/kg静滴,1次/d;对照组加用利巴韦林10～15 mg/kg静滴,1次/d。疗程5～7 d,治疗结束后,随访3～7 d。观察比较两组体温、咳嗽、肺部啰音消失时间及治疗均平天数。结果治疗组治愈26例,有效8例,总有效率是94.44%(34/36);对照治愈22例,有效6例,总有效率77.78%(28/36)。治疗组临床总有效率高于对照组,差异有统计学意义(P<0.05)。治疗期间两组均无严重不良反应。结论炎琥宁联合头孢呋辛钠治疗儿童社区获得性肺炎,具有较好的临床疗效,安全,值得临床使用。
Objective To observe the effectiveness and safety of yanhuning injection（potassium dehydroandrographolide suc- cinate for Injection） combined with Cefuroxime on community-acquired pneumonia in children. Methods Total 72 Children with community-acquired pneumonia were randomly divided into two groups：36 in each group. Both groups were given cefuroxime in- travenously dripped 60 -80 mg/kg each time and once a day;Yanhuning injection intravenously dripped ,5 -7 mg,/kg each time and once a day was added to the treatment group, the control group was treated with Ribavirin injection intravenous dripped, 10 - 15 mg/kg each time and once a day. The therapeutic course was 5 -7 days. A three to seven days follow-up study was performed by the end of the treatment to compare the body temperature, the time of coughing disappearance, the time of lung sound d/sap- pearance,and the days after the treatment of the two groups. Results After treatment,26 cases were totally recovered, 8 cases was partially recovered, and the total effective rate was 94.44% （34/36） after the treatment ;22 cases were totally recovered. 6 cases were partially recovered and the total effective rate was 77.78% （28/36）. The clinical total effective rate of treatment group is clearly better than that of control group（ P 〈 0.05 ）. NO adverse reaction occurred during the therapeutic course. Conclusion The clinical effect of yanhuning injection with cefuroxime for community-acquired pneumonia in children was good and safe and therefore can be used in clinic.
出处
《中华全科医学》
2013年第6期891-891,918,共2页
Chinese Journal of General Practice
关键词
社区获得性肺炎
儿童
炎琥宁
疗效
Community-acquired pneumonia
Children
Potassium dehydroandrographolide succinate for injection
Therapy
