摘要
评价紫杉醇对晚期鼻咽癌的客观疗效及毒副反应。方法 :采用紫杉醇175mg/m2,3h静脉滴注 (每3周1次 )方案共治疗晚期鼻咽癌病人22例 ,所有病人均接受两个疗程以上的化疗。结果 :22例病人均可评价疗效 ,有7例病人达到PR ,有效率为31 .82 %。主要毒副反应为骨髓抑制、恶心和呕吐、肌痛和关节痛、脱发等。大部分病人为Ⅰ～Ⅱ度反应 ,病人耐受良好。经常规预防用药后 ,未观察到有严重的过敏反应。结论 :紫杉醇是一种对晚期鼻咽癌有效的化疗药物 ,该剂量的紫杉醇临床使用较为安全 ,值得进一步的临床研究。
Objective: To evaluate the objective anti tumor efficacy and safety of paclitaxel in the treatment of nasopharyngeal carcinoma Methods: Twenty two cases of advanced nasopharyngeal carcinoma were administrated175 mg/m2 paclitaxel by iv infusion for 3 hours and repeated every 3 weeks Allthe patients were received at least a cycles of the treatment Result: There were 7 cases ceclived patients response in the whole group The objective response rate was 31 82% The major toxicity included neutropenia, nausea vomiting, arthralgia, myalgia, and alopecia The severity of these side effects was mild to moderate and well tolerated All patients were pretreated with dexamethasone, diphenhydramine and cimetidine No severe hypersensitivity reaction was observed Conclusion: Paclitaxel is a effective drug in the treatment of nasopharyngeal carcinoma The dosage of paclitaxel used in this clinical study is safe Further clinical investigation should be warranted
出处
《癌症》
SCIE
CAS
CSCD
北大核心
2000年第8期811-813,共3页
Chinese Journal of Cancer
关键词
鼻咽肿瘤
紫杉醇
化学疗法
Nasopharyngeal neoplasms
Paclitaxel
Chemotherapy
