摘要
目的 :在应用雷尼替丁加甲硝唑 (对照组 )的基础上加用醋氨己酸锌 (治疗组 )治疗有幽门螺杆菌 (Hp)感染的慢性胃炎和消化性溃疡患者 10 4例 ,观察醋氨己酸锌对 Hp阳性的胃炎和消化性溃疡患者的治疗效果。方法 :对照组给予雷尼替丁15 0 m g,bid,甲硝唑 2 0 0 m g,qid;治疗组在对照组的基础上加用醋氨己酸锌 30 0 m g,tid,共 4wk。结果 :治疗组的 Hp清除率明显高于对照组 (P<0 .0 5 ) ;消化性溃疡的愈合率虽高于对照组 ,但统计学上差异无显著性 (P>0 .0 5 )。结论 :醋氨己酸锌、雷尼替丁、甲硝唑三联疗法治疗 Hp阳性的慢性胃炎和消化性溃疡其 Hp的清除率明显高于对照组。
AIM: One hundred and four cases (treatment group) suffered from chronic gastritis and peptic ulcer with Helicobacter pylori ( Hp ) infection were given zinc acexamate, ranitidine and metronidazole, Sixty three cases (control group) were given ranitidine and metronidazole. Treatment effect of zinc acexamate for chronic gastritis and peptic ulcer with positive Hp were observerd. METHODS: Treatment group and control group was given ranitidine 150 mg, each twice daily and metronidazole 200 mg each four times daily, treatment group were given zinc acexamate 300 mg, each three times daily in addition, in all 4 wk. RESULTS: Eradication rate of Hp in treatment group was significantly higher than that of control group ( P <0 05). Cure rate of peptic ulcer was also higher than that of control group, but discrepancy was not significant at statistics ( P >0 05). CONCLUSION: Zinc acexamat combined with ranitidine and metronidazole are effective in eradication of Hp .
出处
《中国临床药学杂志》
CAS
2000年第4期211-213,共3页
Chinese Journal of Clinical Pharmacy
关键词
幽门螺杆菌
醋氨己酸锌
雷尼替丁
甲硝唑
Helicobacter pylori
zinc acexamate
ranitidine
metronidazole
gastritis
peptic ulcer
