摘要
目的 探讨类风湿关节炎患者血清人软骨糖蛋白39（HC gP39）、骨桥蛋白（OPN）及类风湿因子（RF）水平变化及其临床意义。方法 采用ELISA法检测98例类风湿关节炎患者（观察组）血清HC gP39、OPN含量,免疫散射浊度法检测RF水平,并与98例健康人（对照组）比较分析。结果 观察组HC gP39、OPN和RF水平均显著高于对照组（t=20.25、32.71、36.34,均P＜0.01）,且观察组中活动期患者血清HC gP39、OPN和RF水平高于非活动期（t=24.22、45.62、50.15,均P＜0.05）;RA患者I期与II期、II期与III期、III期与Ⅳ期血清HC gP39、OPN水平差异均有统计学意义（F=18.48、12.36,均P＜0.05）;相关性分析表明,RA患者血清RF水平与HC gP39、OPN水平呈正相关（r=0.682、0.656,均P＜0.01）,HC gP39水平与OPN也呈正相关（r=0.608,P＜0.01）。结论 HC gP39、OPN及RF在类风湿关节炎发生发展过程中可能起重要作用,其可作为判断类风湿关节炎活动性和不同分期的重要指标之一。
Objective To explore the changes and clinical significance of serum human cartilage glycoprotein-39（HC gP39）,osteopontin（OPN） and rheumatoid factor（RF） in patients with rheumatoid arthritis（RA）.Methods Serum HC gP39,OPN levels were measured by ELISA in 98 patients with RA and 98 healthy controls.Serum RF was detected by nephelometric immunoassay.Results The serum HC gP39,OPN and RF levels of RA group were significantly higher than the healthy control group（t=20.25,32.71,36.34,all P〈0.01）,and serum HC gP39,OPN and RF levels in active phase patients were higher than the inactive phase patients（t=24.22,45.62,50.15,all P〈0.01）.The levels of serum HC gP39,OPN increased gradually with the increase of the staging severity（F=18.48,12.36,all P〈0.05）.The serum level of RF was positively correlated with the levels of HC gP39,OPN in patients with RA（r=0.682,0.656,all P〈0.01）,the serum level of HC gP39 was positively correlated with the level of OPN（r=0.608,P〈0.01）.Conclusion The HC gP39,OPN and RF reflect situation of RA patients and have close relationship with the clinical progression of RA,which can be used as one of important indexes to judge RA activity and different staging.
出处
《中国基层医药》
CAS
2013年第12期1837-1839,共3页
Chinese Journal of Primary Medicine and Pharmacy
