期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

缺氧诱导因子1α调控内皮素1表达在高糖诱导肾小管上皮细胞转分化中的作用 被引量：4

原文传递
导出
摘要 糖尿病肾病（DN）是终末期肾脏病（ESRD）的主要原因。也是一类以进行性肾间质纤维化（RIF）为特征的疾病。研究表明在DN状态下，肾脏固有细胞如系膜细胞、
作者 唐琳 李慧 张娜娜 陈慧娟 房豫东 王刘伟 刘章锁
机构地区 郑州大学第一附属医院肾内科郑州大学肾脏病研究所
出处 《中华肾脏病杂志》 CAS CSCD 北大核心 2013年第5期375-377,共3页 Chinese Journal of Nephrology
基金 河南省高等学校青年骨干教师资助计划（2010GGJS-004）
关键词 肾小管上皮细胞转分化 缺氧诱导因子1Α 高糖诱导 内皮素1 终末期肾脏病 调控 肾间质纤维化 糖尿病肾病
分类号 R692 [医药卫生—泌尿科学] R587 [医药卫生—内分泌]
  • 相关文献

参考文献5

  • 1Simonson MS. Phenotypic transitions and fibrosis in diabeticnephropathy. Kidney Int, 2007, 71: 846-854.
  • 2Sun S, Ning X. Zhang Y,et al. Hypoxia-inducible factor-1 alphainduces Twist expression in tubular epithelial cells subjected tohypoxia, leading to epilhelial - to - mesem hymal transition.Kidney Int, 2009, 75: 1278-1287.
  • 3Sasser JM, Sullivan JC. Hobbs JL, et al. Endothelin A receptorl)lockade reduces dial)etic renal injury via an anti - inflammatorymechanism. J Am Sot' Nephrol, 2007, 18: 143-154.
  • 4唐琳,易润,杨冰,李慧,陈慧娟,王刘伟,刘章锁.缬沙坦对糖尿病肾病大鼠肾间质纤维化的作用[J].中华肾脏病杂志,2012,28(8):633-638. 被引量：17
  • 5Neuhofer W, Pittrow I). Role of endothelin and endothelinreceptor antagonists in renal disease. Eur J Clin Invest, 2006.36 Suppl 3: S78-S88.

二级参考文献10

  • 1Eitner F, Floege J. Therapeutic targets for prevention and regression of progressive fibrosing renal diseases. Curr Opin Investig Drugs, 2005, 6: 255-261.
  • 2Ban CR, Twigg SM. Fibrosis in diabetes complications: Pathogenic mechanisms and circulating and urinary markers. Vasc Health Risk Manag, 2008, 4: 575-596.
  • 3Zhang S, Zhang Y, Wei X, et al. Expression and regulation of a novel identified tnfaip8 family is associated with diabetic nephropathy. Biochim Biophys Acta, 2010, 1802: 1078-1086.
  • 4Bernadet-Monrozies P, Rostaing L, Kamar N, et al. The effect of angiotensin-converting enzyme inhibitors on the progression of chronic renal failure. Presse Med, 2002, 31: 1714-1720.
  • 5Koo JW. Renal interstitial fibrosis and angiotensin inhibition. Electrolyte Blood Pressure, 2006, 4: 35-43.
  • 6Singh DK, Winocour P, Farrington K. Mechanisms of disease: the hypoxic tubular hypothesis of diabetic nephropathy. Nat Clin Pract Nephrol 2008, 4: 216-226.
  • 7Liu Y. Renal fibrosis: new insights into the pathogenesis and therapeutics. Kidney Int, 2006, 69: 213-217.
  • 8Duymelinck C, Deng JT, Dauwe SE, et al. Inhibition of the matrix Metalloproteinase system in a rat model of chronic cyclosporine nephropathy. Kidney Int, 1998, 54: 804-818.
  • 9唐琳,郭青,张翠翠,刘章锁,张晓雪.缺氧诱导因子1α介导的信号通路在血管紧张素Ⅱ诱导肾间质纤维化中的作用[J].中华肾脏病杂志,2011,27(3):194-197. 被引量：7
  • 10王伟铭,陈楠,俞海瑾,李娅,董德长.低氧对肾小管上皮细胞转化生长因子β1表达及增殖的影响[J].中华肾脏病杂志,2002,18(3):204-206. 被引量：6

共引文献16

同被引文献49

  • 1Montserrat B Duran-Salgado,Alberto F Rubio-Guerra.Diabetic nephropathy and inflammation[J].World Journal of Diabetes,2014,5(3):393-398. 被引量：181
  • 2张旭升,张勇刚.尾加压素Ⅱ与冠心病[J].中国心血管病研究,2007,5(4):303-305. 被引量：5
  • 3赵爱青,马存根,赵森.大鼠肾组织中组织型转谷氨酰胺酶和结缔组织生长因子表达的研究[J].山西医药杂志,2007,36(7):583-585. 被引量：2
  • 4Meng X M,Nikolic-Paterson D J,Lan H Y.Inflammatory processes in renal fibrosis[J].Nat Rev Nephrol,2014,10(9):493.
  • 5Leung K C,Tonelli M,James M T.Chronic kidney disease following acute kidney injury-risk and outcomes[J].Nat Rev Nephrol,2013,9(2):77.
  • 6Lawson J,Elliott J,Wheeler-Jones C,et al.Renal fibrosis in feline chronic kidney disease:Known mediators and mechanisms of injury[J].Vet J,2014,Epub ahead of print.
  • 7Eddy A A.Overview of the cellular and molecular basis of kidney fibrosis[J].Kidney Int Suppl(2011),2014,4(1):2.
  • 8Chen W C,Lin H H,Tang M J.Regulation of proximal tubular cell differentiation and proliferation in primary culture by matrix stiffness and ECM components[J].Am J Physiol Renal Physiol,2014,307(6):F695.
  • 9Liu Y.Epithelial to mesenchymal transition in renal fibrogenesis:pathologic significance,molecular mechanism,and therapeutic intervention[J].J Am Soc Nephrol,2004,15(1):1.
  • 10Yang L,Humphreys B D,Bonventre J V.Pathophysiology of acute kidney injury to chronic kidney disease:maladaptive repair[J].Contrib Nephrol,2011,174:149.

引证文献4

二级引证文献47

中华肾脏病杂志
2013年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部