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可溶性晚期糖基化终产物受体基础与临床研究新进展 被引量:4

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摘要 晚期糖基化终产物受体(receptor for advanced glycation end-products,RAGE)是晚期糖基化终产物(advanced glycation end products,AGEs)最具特征的受体之一,通过与AGEs的结合,可促进炎症反应并参与多种病理过程。可溶性RAGE(soluble forms of RAGE,sRAGE)是RAGE的可溶性形式,可阻止RAGE与其相关的促炎配体(AGEs,高流变簇盒蛋白1,S100蛋白质)结合。目前越来越多的研究发现sRAGE可作为生物标志物或者内源性蛋白因子阻止RAGE介导的疾病发生,表明sRAGE在众多疾病的发生发展中有着举足轻重的作用。鉴于此,作者主要对sRAGE在相关疾病(例如心血管疾病、糖尿病、高胆固醇血症、慢性肾脏病、免疫/炎症性疾病等)基础与临床研究中的进展进行综述。
作者 沈潇 刘乃丰
机构地区 东南大学医学院
出处 《东南大学学报(医学版)》 CAS 2013年第3期364-369,共6页 Journal of Southeast University(Medical Science Edition)
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