摘要
目的观察复方多囊调经汤治疗多囊卵巢综合征胰岛素抵抗(insulin resistance,IR)的疗效及对激素水平的影响。方法将在作者医院门诊就诊符合多囊卵巢综合征标准的98例患者随机分成两组,中药治疗组用复方多囊调经汤,西药治疗对照组口服二甲双胍。观察二组患者治疗前后临床表现、双侧卵巢体积、卵泡数目及血清性激素水平。结果中药治疗组和西药治疗组总有效率分别为88.0%和54.1%(P<0.05),中药治疗组和西药治疗组妊娠率分别为28.00%和6.25%(P<0.05)。与治疗前比较,两组治疗后血清胰岛素(insulin,INS)、促黄体生成素(luteinizing hormone,LH)、血清睾酮(testoserone,T)水平降低,雌激素(estradiol,E2)水平升高(P均<0.05)。与治疗前比较,中药治疗组治疗后双侧卵巢体积缩小,卵泡数减少,有统计学差异(P<0.05),而西药治疗组在治疗后,双侧卵巢体积、卵泡数均无明显差异(P>0.05)。结论复方多囊调经汤治疗多囊卵巢综合征IR具有良好的临床疗效,能够改善患者胰岛素抵抗,提高排卵率及受孕率。
Objective To study the effects of Duonang Tiaojing Tang on polycystic ovary syndrome （PCOS） treat- ment and the hormone levels. Methods A total of 98 patients with PCOS administrated in our hospital were randomly di- vided into Chinese medicine （Duonang Tiaojing Tang） treatment group and western medicine （metformin） treatment group. The changes of clinical manifestations, the volume of the ovary, the number of follicles and the levels of hormone were observed. Results The total efficacy rate of Chinese medicine and western medicine treatment groups were 88.0% and 54. 1% respectively （P〈0. 05）. The pregnancy rates of the two groups were 28. 00% and 6. 25% respectively. The levels of insulin （INS）, luteinizing hormone （LH） and testoserone （T） were significantly decreased and the estradiol （E2） level was increased in both groups after treatment compared with those before treatment （all P〈0. 05）. In Chinese medicine treatment group, the volume of both sides of ovaries and the number of follicles were decreased after treatment （P〈0. 05）, and no significant change was found in western medicine treatment group （P〈0. 05）. Conclusion Duonang Tiaojing Tang has good clinical efficacy in treatment of PCOS with INS resistance, can improve INS resistance and in- crease the ovulation and pregnancy rates.
出处
《华南国防医学杂志》
CAS
2013年第6期397-399,405,共4页
Military Medical Journal of South China
基金
国家自然科学基金项目(81072915)
广东省中医药局立项课题(20122190)
