期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

肿瘤坏死因子凋亡微弱诱导剂与妇科肿瘤的研究进展

Tumor Necrosis Factor-like Weak Inducer of Apoptosis and Gynecologic Neoplasms
在线阅读 下载PDF
导出
摘要 肿瘤坏死因子凋亡微弱诱导剂(tumor necrosis factor-like weak inducer of apoptosis,TWEAK)是新发现的肿瘤坏死因子超家族成员,广泛表达于人体各种组织细胞中,通过与其受体成纤维细胞生长诱导因子14(fibroblast growth factor-inducible 14,Fn14)特异性结合发挥生物学效应。TWEAK和Fn14在肿瘤的发生发展中起重要的调控作用,包括诱导细胞凋亡,促进细胞增殖和血管形成,提高细胞侵袭力和炎症效应等。最新研究认为,TWEAK和Fn14与妇科肿瘤的发生发展密切相关,可能成为妇科肿瘤治疗的新靶点。 Tumor necrosis factor-like weak inducer of apoptosis （TWEAK） is a new member of the TNF family, which widely expressed in human tissues. TWEAK plays biological roles by combining specifically its receptor, fibroblast growth factor-inducible 14 （Fnl4）. TWEAK -Fnl4 system is important in regulating tumor development and prognosis, including cell apoptosis, tumor hyperplasia, differentiation, angiopoiesis, invasion and inflammation. It was demonstated that the TWEAK -Fnl4 signaling was related to gynecologic tumors, and that TWEAK -Fnl4 maybe a potential candidate target for treatment of gynecologic neoplasms.
作者 马宁 邱丽华
机构地区 上海交通大学医学院附属仁济医院妇产科
出处 《国际生殖健康／计划生育杂志》 CAS 2013年第3期211-213,共3页 Journal of International Reproductive Health/Family Planning
关键词 生殖器肿瘤 女(雌)性 肿瘤坏死因子类 TNF相关凋亡诱导配体 肿瘤坏死因子凋亡微弱诱导剂 成纤维细胞生长诱导因子14 Genital neoplasms,female Tumor necrosis factors TNF-related apoptosis-inducing ligand Tumor necrosis factor-like weak inducer of apoptosis Fibroblast growth factor-inducible 14
分类号 R737.3 [医药卫生—肿瘤]
  • 相关文献

参考文献20

  • 1Chicheportiche Y, Bourdon PR, Xu H, et al. TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis[J]. J Biol Chem, 1997,272(51 ):32401-32410.
  • 2Wiley SR,Cassiano L, Lofton T, et al. A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis [J]. Immunity, 2001,15(5 ) : 837-846.
  • 3Meighan-Mantha RL, Hsu DK, Guo Y, et al. The mitogen- inducible Fn14 gene encodes a type I transmembrane protein that modulates fibroblast adhesion and migration [J]. J Biol Chem, 1999,274(46) : 33166-33176.
  • 4Bover LC, Card6-Vila M,Kuniyasu A, et al. A previously unrecognized protein-protein interaction between TWEAK and CD163:potential biological implications[J]. J Immunol,2007, 178(12) :8183-8194.
  • 5He F,Dang W,Saito K,et al. Solution structure of the cysteinerich domain in Fn14,a member of the tumor necrosis factor receptor superfamily [J]. Protein Sci, 2009,18 (3) : 650-656.
  • 6Michaelson JS,Burkly LC. Therapeutic targeting of TWEAK/Fn14 in cancer:exploiting the intrinsic tumor cell killing capacity of the pathway [J]. Results Probl Cell Differ, 2009,49:145-160.
  • 7Zhou H, Marks JW, Hittelman WN, et al. Development and characterization of a potent immunoconjugate targeting the Fnl4 receptor on solid tumor cells [J]. Mol Cancer Ther, 2011,10(7): 1276-1288.
  • 8Whitsett TG,Cheng E,Inge L,et al. Elevated expression of Fn14 in non-small cell lung cancer correlates with activated EGFR and promotes tumor cell migration and invasion [J]. Am J Pathol, 2012,181(1):111-120.
  • 9Watts GS,Tran NL,Berens ME,et al. Identification of Fn14/ TWEAK receptor as a potential therapeutic target in esophageal adenocarcinoma [J]. Int J Cancer,2007,121(10) :2132-2139.
  • 10李俊红,罗雅玲,赖文岩,王蔚盈,宫静.地塞米松对哮喘小鼠肺组织中TWEAK及其受体Fn14表达的调节作用[J].细胞与分子免疫学杂志,2012,28(11):1138-1141. 被引量：6

二级参考文献14

  • 1A1-Muhsen S,Johnson JR,Hamid Q. Remodeling in asthma[J].Journal of Allergy and Clinical Immunology,2011,(03):451-462.
  • 2Sanz AB,Justo P,Sanchez-Nino MD. The cytokine TWEAK modulates renal tubulointerstitia inflammationl[J].Journal of the American Society of Nephrology,2008,(04):695-703.doi:10.1681/ASN.2007050577.
  • 3Winkles JA. The TWEAK-Fn14 cytokine-receptor axis:discovery,biology and therapeutic targeting[J].Nature Reviews Drug Discovery,2008,(15):411-425.
  • 4Dohi T,Borodovsky A,Wu P. TWEAK/Fn14 pathway:a nonredundant role in intestinal damage in mice through a TWEAK/intestinal epithelialell axis[J].Gastroenterology,2009,(03):912-923.
  • 5Munoz-Garcia B,Madriqal-Matute J,Moreno JA. TWEAKFn14 interaction enhances plasminogen activator inhibitor 1 and tissue factor expression in atherosclerotic plaques and in cultured vascular smooth muscle cells[J].Cardiovascular Research,2011,(01):225-233.
  • 6Burkly LC,Michaelson JS,Zheng TS. TWEAK/Fn14 pathway:an immunological switch for shaping tissue responses[J].Immunological Reviews,2011,(01):99-114.
  • 7Saitoh T,Nakayama M,Nakano H. TWEAK induces NF-kappaB2 p100 processing and long lasting NF-kappaB activation[J].Journal of Biological Chemistry,2003,(38):36005-36012.
  • 8Cuenca J,Goren N,Prieto P. Selective impairment of nuclear factor-kappaB-dependent gene transcription in adult cardiomyocytes:relevance for the regulation of the inflammatory response in the heart[J].American Journal of Pathology,2007,(03):820-828.
  • 9Yang M,Wu J,Martin CM. Important role of p38 MAP kinase/NF-kappaB signaling pathway in the sepsis-induced conversion of cardiac myocytes to a proinflammatory phenotype[J].American Journal of Physiology-Heart and Circulatory Physiology,2008,(02):H994-H1001.
  • 10Dharmapatni AA,Smith MD,Crotti TN. TWEAK and Fn14 expression in the pathogenesis of joint inflammation and bone erosion in rheumatoid arthritis[J].Arthritis Research & Therapy,2011,(02):R51.

共引文献5

国际生殖健康／计划生育杂志
2013年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部