摘要
为探讨阿霉素 (ADR)对心脏的慢性毒性作用 ,将新西兰纯种兔 18只随机分成 ADR组和对照组 .ADR组每周静脉注射一次生理盐水配制的 ADR,每公斤体重 2 mg,共 8次 .对照组仅注射生理盐水 .于末次注射后 3周 ,测量兔的心输出量 (CO)、颈动脉压 (BP)、颈动脉平均压 (MAP)、左心室收缩压 (L VSP)和左心室舒张末压 (L VEDP)及心肌肌浆网 (SR)的 Ca2 + - ATP酶活性和血清一氧化氮 (NO)的含量 .结果表明 ,ADR组 CO、BP、MAP、L VSP和 SR的 Ca2 + - ATP酶活性均明显低于对照组 ;L VEDP和血清 NO的含量明显高于对照组 ;ADR组 CO和 VW/ BW之间存在负相关 (P<0 .0 1) ;肌浆网 Ca2 + - ATP酶活性和 CO存在正相关 (P<0 .0 5) .提示治疗剂量阿霉素可使心脏功能下降 ,而血清 NO含量的升高和心肌细胞肌浆网 Ca2 + -
To explore the toxic effect of adriamycin(ADR) on the myocardium,18 pure New Zealand rabbits were assigned randomly to ADR group( n =9) and control group( n =9). Measurements were made on heart rate(HR), cardiac output(CO), blood pressure(BP), mean artery pressure(MAP), left ventricular systolic pressure(LVSP), left ventricular end diastole pressure(LVEDP),sarcoplasmic reticulum(SR) Ca 2+ ATPase activity, nitric oxide(NO) content of serum. The result showed that CO, BP, MAP, LVSP and SR Ca 2+ ATPase activity were significantly decreased in the ADR group compared with the control group.LVEDP and NO level of serum were significantly increased in ADR group. CO correlated with VW/BW and SR Ca 2+ ATPase activity respectively,suggesting that therapeutic dosage of ADR could inhibit the cardiac function while the elevated NO content and the decreased SR Ca 2+ ATPase activity could be the causes.
出处
《科技通报》
2000年第5期392-395,共4页
Bulletin of Science and Technology
