摘要
[目的]探讨联合检测血清甲胎蛋白(AFP)及甲胎蛋白异质体(AFP-L3)含量在肝癌诊断中的意义。[方法]采用全自动化学发光分析技术检测185例肝癌患者、225例肝良性病变患者以及200名健康对照中血清AFP和AFP-L3的含量。[结果]肝癌组、肝脏良性病变组AFP、AFP-L3值均高于正常对照组(P<0.05),肝癌组AFP和AFP-L3水平均高于肝脏良性病变组(P<0.05)。AFP诊断肝癌的灵敏度为68.11%,特异性为80.94%;而AFP-L3灵敏度为83.78%,特异性为96.00%;AFP及AFP-L3联合检测的灵敏度为93.51%,特异性为78.35%。[结论]AFP、AFP-L3联合检测对肝癌早期诊断及鉴别诊断具有一定意义。
[Purpose] To explore the significance of combined detection of serum alpha-fetoprotein（AFP） and Alpha-fetoprotein heterogeneity （AFP-L3） in the diagnosis for liver cancer. [Methods] Automatic chemiluminescent analysis technique was used to detect the AFP and AFP-L3 level in 185 cases with liver cancer,225 cases with benign liver lesion and 200 healthy controls.[Results] AFP and AFP-L3 levels in liver cancer group and benign liver lesion group were significantly higher than those in control group （P0.05） ; AFP and AFP-L3 levels in liver cancer group were significantly higher than those in benign liver lesion group （P0.05） . The sensitivity and specificity of AFP for diagnosing liver cancer were 68.11% and 80.94% respectively, and those of AFP-L3 were 83.78% and 96.00% respectively. The sensitivity and specificity of combined AFP with AFP-L3 was 93.51% and 78.35% . [Conclusion] Combined detection of AFP and AFP-L3 is positively significant for early diagnosis and differential diagnosis in liver cancer.
出处
《中国肿瘤》
CAS
2013年第5期406-408,共3页
China Cancer
关键词
肝癌
甲胎蛋白
甲胎蛋白异质体
liver cancer
alpha-feto-protein
alpha-feto-protein heterogeneity（AFP-L3）
