摘要
目的:探讨沙棘对急性酒精摄入小鼠肝、脑抗氧化系统的影响。方法:雄性ICR小鼠60只,随机分为阴性对照组、酒精模型组和沙棘低、中、高剂量组,各给药组沙棘剂量为:0.6、3、6g/kgbw。连续给药14d。自第15日起,每日给药1h后,酒精模型组和沙棘各剂量组用40%酒精ig,15mL/kg体重,至第20日结束。取小鼠肝脏和脑组织,测定还原型谷胱甘肽(GSH)、丙二醛(MDA)、过氧化氢酶(CAT)和总抗氧化能力(T-AOC)的活性或含量。结果:与酒精模型组相比,沙棘各剂量组肝脏组织中的GSH含量升高,低剂量组中的CAT活性升高,中、高剂量组中的T-AOC活性升高;低、高剂量组脑组织中的GSH含量升高,中、高剂量组中的T-AOC活性升高。结论:沙棘对酒精所致小鼠肝脏和脑组织的氧化应激具有明显的缓解作用。
Objective： Exploration the effects of Hippophae rhamnoides L on antioxidant system in the liver and brain of mice with acute alcohol administration. Methods： Male ICR mice were divided randomLy into five groups, including control group, alcohol model group and 0.6, 3, 6 g/kg bw Hippophae rhamnoides L. groups. Continuous administration for 14 days, since fifteenth, the daily after administration of 1 h, alcohol model group and Hippophae rhamnoides L. in different dosage groups with 40% alcohol by intragastric 15 mL/kg bw, end to twentieth days. Measured the activity of GSH, MDA, CAT and T-AOC in the liver and brain tissues of mice. Results： Compared with alcohol model, Hippophae rhamnoides L. in different dosage groups in liver tissue GSH content increase, low dose group of increased the activity of CAT, in the high dose group, the increase of T-AOC activity; in the low and high dose group of brain tissue GSH content increased, in the middle dose and high dose group increased the activity of T-AOC. Conclusion： Hippophae rhamnoides L. on alcohol induced mouse liver and brain oxidative damage had obvious relieving.
出处
《食品科技》
CAS
北大核心
2013年第6期79-81,共3页
Food Science and Technology
基金
吉林省科技发展计划项目(201105089)
关键词
沙棘
肝脏
脑
酒精
抗氧化系统
Hippophae rhamnoides L.
liver
brain
alcohol
antioxidant system
