摘要
目的:探讨肺表面活性物质(PS)预防新生儿呼吸窘迫综合征(NRDS)的疗效。方法:将2008年1月～2012年8月住院治疗胎龄<32周,体重<1 500 g的60例早产儿随机分为治疗组和对照组。两组均给予对症支持治疗,其中治疗组在此基础上给予PS进行治疗。观察两组患儿NRDS发生率、机械通气率、用氧时间,72 h内血气分析改善情况等。结果:治疗组在NRDS、机械通气例数、比例均明显低于对照组,差异均有明显的统计学意义(P<0.01),并且总用氧时间明显短于对照组,差异有明显的统计学意义(P<0.01),并且血气分析改善情况明显优于对照组。结论:对早产儿应用PS可降低NRDS发生率,值得临床推广应用。
Objective： To explore clinical effect of application pulmonary surfactant （PS） prevention of preterm infants with re- spiratory distress syndrome （NRDS）. Methods： January 2008 - August 2012 to inpatient treatment for gestational age 〈 32 weeks, weight 〈 1 500 g of 60 cases of premature infants were randomly divided into treatment and control groups. Infants in the two groups were given symptomatic and supportive therapy, infants in the treatment group were given PS treatment additionally. NRDS incidence rate, mechanical ventilation, oxygen time, 72 h in blood gas analysis were observed to improve the situation. Results： NRDS, mechanical ventilation case numbers, percentages were significantly lower in treatment group than those of control group, the differences were statistically significant （P 〈 0. 01 ） , and the total oxygen time was significantly shorter than that of control group, the difference was statistically significant （ P 〈 0. 01 ）, and blood gas analysis to improve the situation was significantly better than that of control group. Conclusion： Premature application of PS can reduce the incidence of NRDS, which is worthy of clinical application.
出处
《中国妇幼保健》
CAS
北大核心
2013年第18期2919-2921,共3页
Maternal and Child Health Care of China
关键词
早产儿
呼吸窘迫综合征
肺表面活性物质
Premature infants
Respiratory distress syndrome
Pulmonary surfactant
