摘要
目的初步探讨有复发高危因素的根治性宫颈切除术后宫颈癌患者(IA、IB1期)的辅助化疗的可行性。方法收集2004年7月至2011年4月因宫颈癌行根治性宫颈切除术、术后病理存在复发高危因素接受顺铂及5-氟尿嘧啶(PF)方案化疗患者的病例资料,进行回顾性分析并复习文献。结果行根治性宫颈切除术患者共34例,其中术后病理存在复发高危因素共6例(17.6%),3例充分知情同意后希望继续保留生育功能而接受顺铂及5-氟尿嘧啶(PF)方案辅助化疗。其中2例患者成功分娩。随诊16～65个月,均无瘤生存。结论对于根治性宫颈切除术后病理存在复发高危因素、有强烈保留生育的要求的患者,术后使用PF辅助化疗是可行的,为其完成生育提供可能,但治疗后无瘤生存时间仍需要大样本研究加以证实。
Objective： To investigate the feasibility of adjuvant chemotherapy for patients with cervical cancer （stage IA, IB1）and high-risk recurrence factor after radical trachelectomy. Methods： The patients with radical trachelectomy（RT）for cervical cancer（stage IA, IB1）followed by chemotherapy of cisplatin and 5-fluoruoracil were admitted in Peking Union Medical College Hospital from July 2004 to April 2011. The clinical data of those patients were analyzed retrospectively. The literatures associated with adjuvant chemotherapy for cervical cancer were reviewed. Results： Thirty-four patients with cervical cancer（stage IA, IB1）took radical trachelectomy. Six of them（17.6%） had high risk recurrence factors. Among them, three patients chose to take adjuvant chemotherapy of cisplatin and 5-Fluoruoraeil after fully informed consent,and 2 delivered successfully. The three patients had not recurred during the follow-up period（16-65 months）. Conclusions. For the patients with high risk recurrence factors after radical trachelectomy who still strongly desire to keep their fertility, it is feasible to take adjuvant chemotherapy of cisplatin and 5-fluoruoracil for successful pregnancy.
出处
《生殖医学杂志》
CAS
2013年第6期409-412,共4页
Journal of Reproductive Medicine
基金
国家"十一五"科学支撑计划重点项目(2008BAI57B02)
