摘要
卵巢早衰(POF)指女性40岁以前发生绝经,伴血清卵泡刺激素(FSH)水平升高(通常>40 IU/L)及雌激素水平降低。近年来POF有发病人群年轻化、发病率增高的趋势,严重影响患者的生活质量和身心健康。但大多数患者病因和发病机制不清,属特发性POF。近年来,针对卵泡发育和POF的候选基因研究取得了很多突破性进展,本文就此进行了回顾性总结。
Premature ovarian failure（POF）is defined as the occurrence of amenorrhea before the age of 40 in women,accompanied with an increase of serum FSH to menopausal level（usually over 40 IU/L）, and a decrease of estradiol level. The incidence of POF is increasing but the etiology and pathogenesis are unclear in most cases. This review focuses on the breakthrough of the candidate genes involved in follicular development and POF.
出处
《生殖医学杂志》
CAS
2013年第6期463-467,共5页
Journal of Reproductive Medicine
关键词
卵巢早衰
卵泡发育
候选基因
Premature ovarian failure
Follicular development
Candidate genes
