摘要
目的探讨老年慢性心力衰竭(CHF)患者QRS时限(QRSD)、血浆脑钠肽(BNP)与心功能关系。方法 51例CHF患者,30例对照组。CHF组QRSD分为QRSD1组(QRSD≤120 ms,n=21),QRS2组(QRSD﹥120 ms,n=30)。比较CHF组和对照组及CHF各亚组间QRSD差异,进一步分析QRSD与BNP、左心室射血分数(LVEF)、左室舒张末期内径(LVDED)等因素的相关性,并通过随访观察9～12个月心血管事件的发生率,分为高危组、低危组进行组间比较。结果心衰组QRSD、BNP、LVDED明显高于对照组(P<0.05),LVEF明显低于对照组(P<0.05)。高危组中QRSD亦比低危组明显延长。心衰组QRSD与LVDED,BNP呈正相关,与LVEF呈负相关。结论在慢性CHF患者中联合监测QRSD和BNP,动态评估心衰进展,以利临床制定最佳治疗方案。
Objective To investigative the correlations of QRS duration（QRSD） and B-type natriuretic peptide（BNP）in elderly patients with chronic heart failure（CHF）.Methods The clinical data of 51 cases of elderly patients with CHF and 30 healthy controls were analyzed.Patients with CHF were divided into 2 groups according to QRSD.The following tests were performed： B-type natriuretic peptide levels,QRS duration calculated from 12-lead surface electrocardiography,left ventricular ejection fraction（LVEF）and left ventricular end dilatation diameter（LVDED）measured by ultrasonic cardiograph.Results In heart failure group,QRSD,BNP and LVDED value were obviously higher than those of the control group.LVEF was lower than that in the control.In heart failure group,there was positive correlation between QRSD and BNP as well as with LVDED,and negative correlation between QRSD and LVEF.QRSD was the strongest predictor and showed prognostic value to the primary end point in elderly patients with CHF.Conclusion QRSD is associated with the heart function and BNP of CHF.The joint monitoring of QRSD and BNP in therapy strategy may help to attenuate the cardiac remodeling in patients with CHF.
出处
《安徽医学》
2013年第1期28-30,共3页
Anhui Medical Journal
关键词
QRS时限
心力衰竭
血浆脑钠肽
QRS duration
Heart failure
B - type natriuretic peptide
