摘要
目的:评价肢体骨肉瘤经新辅助化疗后保肢手术治疗的临床疗效和肢体功能。方法:选择2003年1月～2011年1月新辅助化疗结合保肢手术治疗的肢体骨肉瘤42例。ⅡA期26例,ⅡB期16例。广泛切除30例,边缘切除12例。瘤段切除灭活再植18例,人工关节置换术16例,同种异体骨移植术6例;瘤段切除术2例。所有病例切除标本均做多病理切片的坏死率评估。结果:随访1～8年,平均随访5年8个月。42例中3年无瘤生存28例(66.7%),5年以上无瘤生存25例(59.5%),肿瘤局部复发6例(14.3%)。肢体功能评估为优18例,良11例,可4例,差9例,优良率69%。结论:新辅助化疗后保肢手术、术后辅助化疗是治疗肢体骨肉瘤较可行的治疗方法,术前有效化疗是保肢术成功的重要环节,术后辅助化疗对减小复发率和提高生存率有积极的作用。
Objective：Appraisal body osteosarcoma after new auxiliary chemotherapy guarantees clinical curative effect and body function that the extremity surgery treats.Method： 42 cases of body osteosarcomas guarantee after the new auxiliary chemotherapy of the extremity surgery were selected from Jan.2011 to 2013.ⅡA time 26 cases,Ⅱ B time 16 cases.Widely excises 30 cases,the edge excises 12 cases.Lump section excision deactivation plants 18 cases again,artificial joint replacement technique 16 cases,bone allograft transplant technique 6 cases;Lump section excision method 2 cases.All cases were excised the specimen to make the necrosis rate appraisal of multi-pathological section.Result： A follow-up visit for 1 ～ 8 years with a follow-up visit on average for 5 years 8 months.In 42 cases,28 cases with non-lump for 3 years（66.7%）;25 cases with non-lump for 5 years（59.5%）;the tumor recurs partially 6 cases（14.3%）.Body functional evaluation for superior 18 cases,good 11 cases,fairly good 4 cases,poor 9 cases,the excellent rate is 69%.Conclusion： With the chemotherapy to guarantee extremity surgery is an ideal method of treatment,The effective chemotherapy before the surgery is the key to guarantee the extremity;the chemotherapy after surgery is to reduce the recurrence rate and raise the survival rate.
出处
《赣南医学院学报》
2013年第3期350-353,共4页
JOURNAL OF GANNAN MEDICAL UNIVERSITY
关键词
骨肉瘤
新辅助化疗
保肢术
osteosarcoma
neoadjuvant chemotherapy
limb salvage surgery
