摘要
血吸虫病是一种人兽共患、流行广泛的寄生虫病， 严重影响着人群的健康和社会经济的发展。血吸虫在整个生活史过程中，呈现显著的生物学和形态学变化，这种不同发育阶段虫体在形态学和生物学上的变化可能与不同发育阶段虫体蛋白、基因差异表达及独特的代谢和发育过程相关。分析比较不同发育阶段、不同性别之间的差异表达蛋白及基因，鉴定可能与血吸虫生长发育、致病等相关的分子，可为阐明日本血吸虫的生长发育机制，进而为筛选疫苗候选分子、新的诊断抗原及治疗药物靶标奠定基础。该文对日本血吸虫不同发育阶段和不同性别虫体差异表达蛋白及基因的研究进展进行综述。
Schistosomiasis remains one of the most prevalent parasitic zoonosis in human and livestock and continues to be a global public health and social economy concern in the developing countries. In each stage of the life cycle, sehistosome appears distinct characteristics in biology and morphology, which may he relevant to the differential protein and gene expression and special metabolism and development process at different stages. Ana- lyzing the differentially expressed proteins and genes involved in the growth and pathopoiesia could provide a basis for illuminating the development mechanism of sehistosome, and for the screening of vaccine candidates, new diagnosis antigens and new drug targets. The aim of this review is to summarize the recent development in studies on differentially expressed proteins and genes at different development stages and gender of Schistosomajaponicum.
出处
《国际医学寄生虫病杂志》
CAS
2013年第4期216-220,共5页
International JOurnal of Medical Parasitic Diseases
关键词
日本血吸虫
蛋白组
基因组
差异表达
Schistosomajaponicum
Proteome
Genome
Differential expression
