摘要
目的探讨进食对FibroScan检测乙型肝炎肝纤维化的影响。方法 57例乙型肝炎肝纤维化患者分别于早晨空腹(餐前)和餐后2h(餐后)检测肝脏硬度值,同时行肝脏活体组织检查,以病理结果为"金标准",分析餐前和餐后肝脏硬度值的差异。结果餐前和餐后肝脏硬度值差异无统计学意义(P=0.989)。病理检查的结果为:餐前FibroScan诊断S2、S3、S4期的受试者工作特征曲线下面积分别为0.93、0.95、0.97,诊断界值分别为8.1、11.0、17.3kPa;餐后FibroScan诊断S2、S3、S4期的受试者工作特征曲线下面积分别为0.93、0.96、0.95,诊断界值分别为8.0、12.7、16.4kPa。结论早晨空腹和餐后2h肝脏硬度值无明显变化,进食对FibroScan检测乙型肝炎肝纤维化无影响。
Objective To investigate the effect of diets on the accuracy of FibroScan for the assessment of liver fibrosis in patients with chronic hepatitis B （CHB）. Methods Fifty-seven CHB patients underwent both liver stiffness measurement （LSM） and liver biopsy, kSM was performed before meal and 2 hours after meal. With liver biopsy as the gold standard, the differences of I_SM values before and after meal were compared and analyzed. Results The LSM values before and after meal were not significantly dif ferent （P=0.989）. Pathological findings showed that the areas under the receiver operating characteristic curves （AUROCs） were 0.93, 0.95 and 0.97 for patients with liver fibrosis stages 2--4, and the cut-off values were 8.1, 11.0 and 17.3 kPa, respectively, before meal; the AUROCs were 0.93, 0.96 and 0.95 for patients with liver fibrosis stages 2-4, and the cut-off values were 8.0, 12.7 and 16.4 kPa, respectively, after meal. Conclusions LSM values are not significantly different before meal and 2 hours after meal in the morning. Diets have no effect on FibroScan for the assessment of liver fibrosis in CHB Patients.
出处
《传染病信息》
2013年第3期149-151,共3页
Infectious Disease Information
基金
中国肝炎防治基金会王宝恩肝纤维化研究基金面上项目(2010xjs002)
重点项目(2011xjs0408)
关键词
肝纤维化
早期诊断
硬度
liver tibrosis
early diagnosis
hardness
