摘要
临床上结核性胸膜炎易发生胸膜纤维化,对患者肺功能产生不同程度的影响。胸膜纤维化的发病中,胸膜间皮细胞、成纤维细胞、凝血纤溶系统及各种细胞因子相互联系,互为调节影响,发挥重要的作用。结核性胸膜炎发病后的临床进展过程亦与宿主的免疫反应密切相关,CD4+Th3细胞、CD4+Tr1细胞及CD4+CD25+FoxP3+T细胞在结核病程中可能因抑制CD4+Th1细胞免疫应答功能,从而有利于结核病的感染持续,促进胸膜纤维化的形成。目前对机体在结核性胸膜炎发病中的免疫反应研究仍多局限于CD4+Th1/Th2细胞的关系,对其他调节性T细胞的免疫调节作用研究报道较少。文中综述结核性胸膜纤维化机制研究进展,介绍间皮细胞及其分泌物、凝血纤溶系统、细胞因子及调节性T细胞CD4+Th3细胞、CD4+Tr1细胞及CD4+CD25+FoxP3+T细胞的免疫调节作用。
Tuberculous pleurisy being prone to pleural fibrosis in clinic can have various degrees of impacts on patientg lung function. In the incidence of pleural fibrosis, pleural mesothelial cells, fiber cells, coagulation and fibrinolysis system, and a variety of cytokines all play an important role through interrelating and mutually adjusting impact. Clinical progression after the onset of tubercu- lous pleurisy is also closely related to the host＇s immune response. CD4 ＋ Th3 cells, CD4 ＋ Trl cells, and CD4 ＋ CD25 ＋ FoxP3 ＋ T cells can facilitate the continuous tuberculosis infections and promote the formation of tuberculous pleura1 fibrosis through inhibition of CD4 ＋ Thl cells immune response function in the course of the tuberculosis At present, most researches on immune response of the body to tu- berculous pleurisy focused on the immune response of CD4 ＋ Thl/Th2 cells, while less studies on the other regulatory T cells of the im- mune regulatory function. Research progress of tuberculous pleural fibrosis mechanism were reviewed in this paper, which will intro- duce, mesothelial cells and its secretion, blood coagulation fibrinolytic system, cytokine and regulatory T cells CD4 ＋ Th3 cells, CD4 ＋ Trl cells and CD4 ＋ CD25 ＋ FoxP3 ＋ T cells of immune regulatory function.
出处
《医学研究生学报》
CAS
北大核心
2013年第7期762-765,共4页
Journal of Medical Postgraduates
关键词
结核病
胸膜纤维化
发病机制
Tuberculosis
Pleural fibrosis
Pathogenesis
