摘要
目的观察氟比洛芬酯不同给药方法在单侧甲状腺瘤切除术后的镇痛效果。方法择期气管插管静脉全麻行单侧甲状腺瘤切除术患者80例,随机分为四组,每组20例。A组于气管插管前静注氟比洛芬酯100mg;B组于气管插管前和手术结束时各静注氟比洛芬酯50mg;C组于手术结束时静注氟比洛芬酯100mg;D组于气管拔管后静注氟比洛芬酯100mg。记录术后0、1、4、8、12h静息和运动状态下的疼痛VAS评分及术后24h总体镇痛评价。记录患者追加镇痛药和不良反应的发生情况。结果术后0、1和4hVAS评分和术后24h总体VAS评分D组明显高于A、B、C组(P<0.05)。静息和运动状态下A、B、C组组间组内VAS评分差异无统计学意义。结论氟比洛芬酯气管插管前和手术结束时分次给药应用于单侧甲状腺瘤切除术后镇痛,效果确切、使用方便、不良反应少。
Objective To study the analgesic effect of flurbiprofen axetil given by different administration methods in the patients undergoing unilateral subtotal thyroideetomy. Methods Eighty patients undergoing unilateral subtotal thyroidectomy were randomly allocated to four groups. Each group has 20 cases. The patients in group A were injected intravenously flurbiprofen axetil 100 mg before intubation. The patients in group B were injected intravenously flurbiprofen axetil each 50 mg before intubation and in the end of the operation. The patients in group C were given intravenous flurbiprofen axetil injection 100 mg in the end of the operation. The patients in group D were injected intravenously flurbiprofen axetil 100 mg after extubation. The analgesic effect was evaluated by VAS score of resting and movement at baseline （0 hour）, 1st, 4th, 8th and 12th hour after surgery, and the postoperative 24-hour total analgesic effect was meansured at the same time. The dose of analgesic drug used postoperatively and the relative side effects were recorded. Results VAS scores of group D were significantly higher than those of group A, B and C at baseline, 1st, and 4th hour （P^0. 05）. No significant difference existed among the VAS scores of groups A, B and C, although the VAS scores of group B were lower than those of group A and C. The value of total 24 hour analgesic effect after surgery was significantly higher in group D than that in groups A, B and C （P〈0. 05）. The side effects of four groups were similar. Conclusion The analgesia with flurbiprofen axetil is effective and the application of this drug before intubation and in the end of the operation is convenient and safe with few side effect in the patient undergoing unilateral subtotal thyroidectomy.
出处
《临床麻醉学杂志》
CAS
CSCD
北大核心
2013年第7期681-683,共3页
Journal of Clinical Anesthesiology
关键词
氟比洛芬酯
镇痛
甲状腺瘤切除术
Flurbiprofen axetil
Analgesia
Subtotal thyroidectomy
